Focusing on the entire cohort, this study seeks to define inter-relationship linkages between the person (“ego”) and other associated participants (“alters”). Previous studies identified linkages through the specification of a family roster and alternate points of contact in the consent process. The relationship data produced would be available for network analysis to determine the impact of the social network on health... more »

Edentulism is the end-product of years of poor oral health, with substantial personal, societal, and economic burden. Tracking the multiple factors contributing to this poor oral health outcome will be possible in the AoU database, and could lead to a much more detailed understanding of the genetic and behavioral risk factors involved, including chronic systemic health problems. This is turn may point to specific interventions... more »

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine wearable technologies that could help push this field of research forward in a valid way for the future. Such technology could be a part of individual studies of stress and disease, and could also be used as a gold standard... more »

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

Modifiable risk factors interact with genes to predict rheumatoid arthritis (RA). Antibodies can be detected in pre-RA, up to 10 years before symptoms.
Goal: Conduct RCT to reduce RA risk factors and delay/prevent RA onset
Methods.Find high risk subjects (+CCP, high polygenetic risk score), monitor for early sx (mHealth), conduct RCT based on motivational interviewing/health coaching vs. basic info intervention to modify... more »