Showing 18 ideas for tag "health-disparities"
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Within a healthy cohort, can genomic and social determinants be used to tailor preventive and primary care recommendations?

This case study focuses on symptoms not identifiable as a "disease" or indication, and based on the risk factors captured in that subset's data, identify what can be done with tailored prevention and primary care prevent the symptoms from becoming syndromes. A participant subset with similar complaints, race/ethn, geographical factors, genetic, and SDH factors might sort out syndromes and treatment that are undiagnosed... more »

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AoU Research Priorities Use Cases

Would the addition of non-selective beta-blockers to cancer therapy result in better survival?

Animal models are compelling that activating the beta-adrenergic pathway (via stress) results in tumor growth and metastasis. Beta-blockers blunt this effect in animals. All of Us could design a randomized intervention trial to test this potential benefit in humans. An observational approach could also be taken with careful attention to pharmacoepi principles and biases such as confounding by indication.

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AoU Research Priorities Use Cases

Is the seminal fluid microbiome associated with incident prostate cancer risk?

Prostate cancer has long been suspected to include an infectious etiology, although no agent has been identified. It is possible that one specific virus or bacterium is not significant, but rather the characteristics of the entire microbiota to which the prostate is exposed (e.g., the abundance and diversity of all microorganisms). This may be capturable by examining the seminal fluid microbiome.

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