Animal models are compelling that activating the beta-adrenergic pathway (via stress) results in tumor growth and metastasis. Beta-blockers blunt this effect in animals. All of Us could design a randomized intervention trial to test this potential benefit in humans. An observational approach could also be taken with careful attention to pharmacoepi principles and biases such as confounding by indication.

Prostate cancer has long been suspected to include an infectious etiology, although no agent has been identified. It is possible that one specific virus or bacterium is not significant, but rather the characteristics of the entire microbiota to which the prostate is exposed (e.g., the abundance and diversity of all microorganisms). This may be capturable by examining the seminal fluid microbiome.

US Wound Registry data confirm outcome of African Americans with lower extremity wounds is worse than in whites, particularly true for DFU outcomes where amputation rates are higher. USWR data confirm use of advanced therapeutics in wound care is determined by payer. Whether a Medicare beneficiary has a secondary insurance determines if they get a cellular product, & use of all advanced therapeutics has changed with rise... more »

By analyzing the social, demographic and economic conditions of the cohort participants, AoU can detect with unprecedented precision which social categories, and on what basis, participate in medical research, and which ones tend to be excluded. In particular, by asking directly to the participants their motivations for participating, and putting these in relation with different sociodemographic parameters, AoU could... more »

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine wearable technologies that could help push this field of research forward in a valid way for the future. Such technology could be a part of individual studies of stress and disease, and could also be used as a gold standard... more »

In animal models, stress is a trigger for tumor growth and metastasis, yet we have not adequately addressed this question in human cancer patients or survivors.

All of Us could longitudinally assess the biological experience of psychosocial stress (via biomarker or wearable technology) at specified times in the cancer survivorship period, and conduct an analysis of time to recurrence or time to death.

This case study focuses on symptoms not identifiable as a "disease" or indication, and based on the risk factors captured in that subset's data, identify what can be done with tailored prevention and primary care prevent the symptoms from becoming syndromes. A participant subset with similar complaints, race/ethn, geographical factors, genetic, and SDH factors might sort out syndromes and treatment that are undiagnosed... more »

Women of African, compared to European, ancestry in the US are 2-3x more likely to be diagnosed with triple negative breast cancer. The causes are unknown, but striking disparities in exposure to a number of potential carcinogens have been identified. Quantifying environmental exposures and linking to electronic health records for breast cancer associated diagnoses would define the extent of disparities, chemical associations... more »

By crossing several kinds of data, also related to the social, demographic, educational and economic conditions, AoU is a unique opportunity to understand with unprecedented precision the role of the social determinants of health. In particular it could disentangle the links among poor health-poor education-poor economic conditions-poor neighborhood-unhealthy lifestyle, and indicate which kind of policies and social reforms... more »

Chronic stress linked to social disadvantage—economic deprivation, exposure to racism and discrimination, etc.—contributes to health disparities. Social stressors vary across the life course, affecting disease risk, progression and outcomes in disadvantaged groups. All of Us cohort data will shed light on mechanisms by which social disadvantage and chronic stress affect physiology, health behavior and overall health,... more »

The purpose of this study is to understand reasons for minimal participation of urban community residents in longitudinal research. The study will also explore expectations of urban community residents as a result of participating in longitudinal research. The study will use qualitative focus group approach of urban community residents in the Midwest.

Assess religiosity as it may relate to social support to buffer stress, which could affect pregnancy length (# weeks gestation) and preterm birth rates.

Black Therapists Rock engages over 19,000 psychotherapists who work with vulnerable populations. We have noticed a correlation of improved health outcomes in clients who have utilized Internal Family Systems (IFS), a psychotherapy model that focuses on healing the emotional wounds developed in childhood. We wish to expand upon this data, by employing more therapists to use this model, while advocating/recruiting participants... more »

Populations of limited health literacy have traditionally been underrepresented in genomic/genetic studies. We propose that All of Us participants complete brief baseline HL survey items as part of the Participant-Provided Information (PPI; The Basics). HL measures can be analyzed in comparison with national estimates and in conjunction with other All of Us measures (e.g., uptake on genetic testing, behavioral outcomes,... more »

From a diverse sample of children in both clinical and non-clinical settings, investigate genetic contributions to a wide range of neurodevelopmental problems (NPs). Individual-variant and polygenic approaches can advance our understanding of the genetic overlap between, and specificity in, different types of NPs. In a large and diverse sample that includes different racial/ethnic and socioeconomic groups, these techniques... more »