2 possible designs:
1) Enroll women diagnosed with preeclampsia (PEC) during current pregnancy and collect data (phenotype & biomarkers), follow up prospectively until cardiovascular events (acute coronary events, strokes, including cardiac surgery)
2) Ambidirectional design: enroll women with a PEC history now having cardiac surgery/cardiopulmonary bypass (CPB); collect biomarkers & clinical outcomes (phenotype after... more »

N/A

Preeclampsia/HELLP syndrome can be caused by many different underlying conditions. If we can determine who would be at risk (either the individual women and/or couples together), perhaps the disease can be prevented by testing their embryos before implantation (IVF), or by having women at risk take Aspirin starting early in their pregnancy.

Enroll sufficient numbers of pregnant women and their offspring to study the causes of pregnancy complications including preeclampsia, preterm birth, still birth, intrauterine growth restriction. Target high-risk pregnancies such as obesity, preexisting diabetes, and gestational diabetes. Follow up long term effect and study genetic contributions in a family-based approach. Obtain maternal samples and placentas for possible... more »