(@mgarciaclosas) kudos icon +

AoU Research Priorities Use Cases

What are the determinants of risk for different breast cancer subtypes?

Breast cancer represents a major public health problem. In 2017, >250,000 women received a first diagnosis of invasive and >60,000 of non-invasive breast cancer in the US. This is a heterogeneous disease with respect to morphologic, molecular and genomic features, defining subtypes with distinct etiology and clinical behavior. Understanding the causes of different subtypes is needed to improve risk assessment and inform... more »

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14 votes
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(@britton.trabert) kudos icon +

AoU Research Priorities Use Cases

Which formulation of newer generation oral contraceptives influence cancer risk?

Oral contraceptive (OC) use is associated with decreased risks of several cancers and current use increases risk for breast cancer. Most studies are limited to women who used early generation OCs—which contained higher estrogen concentrations and androgenic progestins compared to drugs used today. Research suggests that newer drugs are still associated with early breast cancer risk, however the influence on other cancers... more »

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16 votes
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(@moorest) kudos icon +

AoU Research Priorities Use Cases

What are the metabolic features of people who develop cancer, compared with those who do not

Cancer is the 2nd leading cause of death in the United States. Recent discoveries within cancer biology highlight that reprogrammed metabolism is a hallmark of cancer. Whether there are detectable metabolic perturbations that precede and/or predispose to development of cancer in individuals is not known, however. New metabolomics technologies make it possible to assay 1000s of metabolites simultaneously and could be... more »

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32 votes
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(@jdpollockmail.nih.gov) kudos icon +

AoU Research Priorities Use Cases

Persistent opioid use after surgery in previously opioid naive patients

The fundamental question in addiction research is why some people become addicted while others who are exposed abused substances do not. There is an opportunity to answer this question for opioid addiction and respiratory depression in surgical patients. About 5 to 10 percent of surgical patients who are pain free and opioid naïve, given opioids during and after surgery, persist in opioid use 12 months after surgery... more »

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15 votes
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(@fearnp) kudos icon +

AoU Research Priorities Use Cases

What if any are the differences in health outcomes for genetic versus self-reported demographics?

What if any are the differences in terms of cancer incidence and treatment outcomes for genetic demographics (biological sex, ethnicity) versus comparable self-reported demographics (gender, race, nationality)? The goal of this research would be to explore the relative contribution on disease, health, and outcome of genetically determined demographic characteristics versus personal, social or culturally determined demographic... more »

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11 votes
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(@bcuthber) kudos icon +

AoU Research Priorities Use Cases

How can we best determine and validate domains of behavioral functioning to achieve precision assessments for mental disorders?

Assessment and treatment of mental disorders increasingly focus on neurocircuit-based abnormalities in functional domains such as emotion and cognition. There is a need for computational modeling to define and validate critical dimensions of psychopathology, using optimal behavioral tasks and patient-reported outcomes to develop refined diagnoses and outcome measures. Large samples are required for modeling analyses that... more »

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17 votes
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(@jenna.norton) kudos icon +

AoU Research Priorities Use Cases

What characteristics define women with Urinary Incontinence who respond to midurethral sling surgery, versus those who don’t?

Midurethral sling surgery (MuSS) outcomes are inconsistent. We lack knowledge of outcome moderators. This study will identify a prospective subcohort of women aged 18+ with incident successful and unsuccessful MuSS. Hypothesized moderators of MuSS outcome spanning the social ecological model (e.g., urinary microbiome, comorbidities, BMI, physical activity, race, occupation, income) will be compared across those with successful... more »

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10 votes
Ideate
(@jenna.norton) kudos icon +

AoU Research Priorities Use Cases

What characteristics define women with Urinary Incontinence who respond to midurethral sling surgery, versus those who don’t?

Midurethral sling surgery (MuSS) outcomes are inconsistent. We lack knowledge of outcome moderators. This study will identify a prospective subcohort of women aged 18+ with incident successful and unsuccessful MuSS. Hypothesized moderators of MuSS outcome spanning the social ecological model (e.g., urinary microbiome, comorbidities, BMI, physical activity, race, occupation, income) will be compared across those with successful... more »

Voting

20 votes
Ideate
(@measurenutrition) kudos icon +

AoU Research Priorities Use Cases

What is the contribution of dietary patterns and nutritional status to chronic disease susceptibility and prevention?

The top four causes of deaths in the U.S. are diet related and many other troublesome diseases are affected by diet, It will be important therefore to capture nutritional status, food environment, and repeated 24h (ASA24s) dietary intakes along with measures that can validate dietary measures of public policy interest including added sugar, energy, protein, sodium, iron, vitamins, dietary supplements, potassium, fruits... more »

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67 votes
Ideate
(@jasdashmol) kudos icon +

AoU Research Priorities Use Cases

How useful are BMI statistics when determining an individual's health and is it now time to update BMI ranges?

I would gather health stats over the course of five years from people that are within current "healthy" BMI ranges and people that are above and below the guidelines. Monitoring various aspects of their health over a period of five (to ten) years would allow researchers to see if current BMI ranges should be changed.

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33 votes
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(@sujei.valentin) kudos icon +

AoU Research Priorities Use Cases

Sugar addiction and what are the physical and mental damages that ingesting high amounts of sugar during your life can develop?

What I have in mind is to let the world know that sugar is addictive, that it makes us really sick, physically and mentally. I also wish for a cure or a less damaging (or not damaging at all) substitute for this addiction to be found or maybe some regulations in the foods that we eat that are sold in the markets. I compare sugar with cigarettes. They are legal, but they can kill us.

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25 votes
Ideate