AoU Research Priorities Use Cases

See others’ ideas.

Below are the research questions others have already entered. IdeaScale is temporarily closed, but you can read what has been submitted so far. When re-opened, you can leave a comment or vote for the ideas you like. At that time, you'll also be able to submit your own idea.

When you are ready to submit your own idea after IdeaScale is re-opened, click the "Submit New Idea" button in the top right corner. Moderators from our team will review your submission and then add it to the rest of the submitted research questions.

To review the All of Us Research Program's Policy on Posting in IdeaScale, please click here.

AoU Research Priorities Use Cases

What is the diversity of human healthy profiles across diverse populations, age, and sex.

In addition to items mentioned in the protocol: 1) Enroll subjects willing to make all their data (including genomic data, but minus other PHI) open consent. Makes data more accessible and avoids many data management headaches 2) Collect microbiome, PBMCs; use Streck tubes for cell free DNA and RNA 3) Questionaires on food/nutrition and stress should be included 4) Freeze urine and plasma on dry ice ASAP. 5) Ideally also ...more »

Submitted by (@mpsnyder)

Voting

0 votes
Ideate

AoU Research Priorities Use Cases

Can foot amputation be prevented in diabetics with AI powered diagnosis?

Foot amputation is a major problem in diabetics in the south Asia. A small blister or ulcer in the foot can develop into a major complication where the foot/toe needs to be amputated. Due to lack of sensation in the foot, most of the time the injuries are unnoticed. An AI powered solution that involves sensors and certain preliminary tests to prematurely detect the risk of foot amputation in diabetics at an earlier stage ...more »

Submitted by (@srileka.mylvaganam)

Voting

0 votes
Ideate

AoU Research Priorities Use Cases

How do the conversations between doctors and patients affect patient outcomes and future healthcare use?

Research across sociology, psychology, and medicine have found that certain differences in the way doctors speak with patients can improve patient communication about presenting problems, increase patient satisfaction, and even enhance physiological responses to treatment. Collecting transcripts of conversations between patients and their doctors would provide a wealth of qualitative information that could be analyzed ...more »

Submitted by (@ericnsmith)

Voting

0 votes
Ideate

AoU Research Priorities Use Cases

Is optimal musculoskeletal health associated with bladder health?

Musculoskeletal conditions particularly low back pain have been shown to be commonly associated with urinary incontinence throughout the female lifespan. We hypothesize that women with more musculoskeletal pain or injury history will have more LUTS. We postulate that both core muscle and pelvic floor muscle dysfunction contribute to this correlation. We propose to study this in a prospective observational study of women ...more »

Submitted by (@cmfitzgeraldmd)

Voting

0 votes
Ideate

AoU Research Priorities Use Cases

Why is gestational diabetes (GDM) risk highest among select Asian-Americans despite the absence of preconceptional obesity?

Gestational diabetes prevalence is higher among Asian Indians, Filipinos, Southeast Asians, and Chinese compared to White, Black, and Hispanic parturients despite the absence of preconceptional obesity. Dissecting the etiology of elevated GDM risk in these Asian-American subgroups, and evaluating effective interventions (other than weight management) to prevent GDM and reduce future risk of type 2 diabetes are urgently ...more »

Submitted by (@haraneta)

Voting

0 votes
Ideate

AoU Research Priorities Use Cases

Can a AI chatbot solve or reduce the commotion and confusion that arises during an outbreak of epidemic, endemic or a pandemic d

Whenever there is an outbreak of an pandemic disease, say "swine flu", everyone gets alarmed on the symptoms to check if they have actually got it. So a chatbot trained with AI to detect the key symptoms and guide the end user to identify if he is at risk or not, would reduce the excitement among patients and also save general physicians time in effectively attending only the actual patients

Submitted by (@srileka.mylvaganam)

Voting

0 votes
Ideate

AoU Research Priorities Use Cases

Evaluate the impact of circadian clock and sleep on health and diseases prevention, progression, and treatment across lifespan

Circadian clock and/or sleep disruptions have been suggested associated with health and disease outcome. A systematic longitudinal follow up over lifespan is needed to understand the underlining mechanisms. All of Us project could provide such opportunity to evaluate the dynamic relationships of circadian clock and sleep with other multi-level factors, such as, lifestyle (diet, exercise and mental health) and behavior, ...more »

Submitted by (@selfemail2004)

Voting

0 votes
Ideate

AoU Research Priorities Use Cases

Neighborhood-Scale Air Quality Testing for Substances of Concern in Consumer Products + Engagement, Metabolome & Health Tracking

Neighborhoods nominated for testing by underserved, understudied vulnerable persons with environmental injuries and illnesses including toxicant-induced loss of tolerance (TILT), multiple chemical sensitivities, toxicant-induced encephalopathies, myalgic encephalomyelitis (ME), CFS & asthma.   Of particular concern on the neighborhood scale are pesticides and hydrophobic organic chemicals -- especially those emitted ...more »

Submitted by (@b.regenerative)

Voting

0 votes
Ideate

AoU Research Priorities Use Cases

Conduct research to understand the pathogenesis of Lipedema so as to differentiate between Obesity and Lymphedema.

Lipedema is an underdiagnosed or misdiagnosed Adipose Disorder that is often mistaken for Obesity or Lymphedema. It is estimated that 1 out of 9 adult females suffer from this fat disorder that is marked by an abnormal deposition of fat in the lower body that is resistant to diet and exercise. Research into the pathogenesis of Lipedema would lead to better diagnostic methods and treatment modalities. Genetics are thought ...more »

Submitted by (@medlib)

Voting

0 votes
Ideate

AoU Research Priorities Use Cases

How are body fat and activity level related to pregnancy outcomes in normal or high BMI athletes with normal ovulatory function?

The goal would be to examine how body fat, pre-pregnancy, and activity levels before and during pregnancy were related to pregnancy outcomes (e.g., miscarriage, full-term, low birthweight, etc.) in athletes with a normal or high BMI and normal ovulatory function; prior studies focus solely on BMI, which is often an inaccurate measure for athletes. All of Us should collect data on body fat preconception, physical activity ...more »

Submitted by (@mgough)

Voting

0 votes
Ideate

AoU Research Priorities Use Cases

Do diagnostic markers differ across racial and ethnic groups and contribute to health disparities?

The goal of this study is to research underlying causes of health disparities using existing data and novel data sources for example is diagnosis and treatment of diabetes different across ethnic groups, does a1c vary by G6PD genotype and does follow up and a1c target differ by diversity standards.

Submitted by (@andrea.h.ramirez)

Voting

0 votes
Ideate