(@andrea.h.ramirez)

AoU Research Priorities Use Cases

Can mobile health technologies such as FitBit or Apple watch recapitulate known disease monitoring

The goal of this study is to understand if mobile technologies can contribute clinically meaningful metrics. By analyzing mobile technology over time and comparing to available clinical health records, supervised and unsupervised machine learning can be applied to understand potential of this technology in clinical care and outcomes.

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(@andrea.h.ramirez)

AoU Research Priorities Use Cases

Investigate impact of pharmacogenomics on real world prescribing practices and medication use

The goal of this study is to understand pharmacogenetic and other predictors of adverse effects of medications and therapeutic failure enabled by aggregation of claims data and pharmacy fill data from multiple sources over many years. For example, does treatment failure of proton pump inhibitors in genetic hypermetabolizers cause increased surgical procedures and how do drugs interact in patients treated with multiple ...more »

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(@andrea.h.ramirez)

AoU Research Priorities Use Cases

Understand implications of rare deleterious variants in an unselected population

The goal of this study is to ascertain clinical implications of rare genetic variants predicted to be deleterious discovered in individuals not carrying the diagnosis. Using existing phenotypes or potentially with recontact to participants physiological impact of variants on health and disease can be understood.

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(@andrea.h.ramirez)

AoU Research Priorities Use Cases

Investigate penetrance of known disease associated rare variants for rare disease eg APS1

The goal of this study is to ascertain clinical implications of rare variants associated with rare disease such as autoimmune polyglandular syndrome type 1. Whole genome sequencing will discover variants known to cause disease, likely in individuals not carrying the diagnosis. Using existing phenotypes or potentially with recontact to participants physiological impact of variants on health and disease can be understood. ...more »

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(@andrea.h.ramirez)

AoU Research Priorities Use Cases

Estimate risk for common disease such as diabetes from genetic factors, dietary habits, and geolocalization data

Estimate risk for common disease or health outcomes based on known genetic factors combined with novel environmental data types such as proximity to food sources and pollution and laboratory measures of pollutant exposure, for example, what is the relative risk of genetic factors for diabetes compared to dietary habits and proximity to grocery stores?

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(@hiwotjewore)

AoU Research Priorities Use Cases

Conduct a research on the effect of physical exercise on the on post Natal depression.

Cohort study will be done by recruiting mothers at their first year of giving birth to their baby. The intervention can be both health center oriented or home based physical exercise coaching. Weekly Edinburgh post Natal depression scale will be used to followup how their feelings and physical as well as emotional health is being improved. The result can be compared against previously conducted research on mother's or ...more »

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(@eofili)

AoU Research Priorities Use Cases

Can mobile health technology monitor/ track spirometry and detect acute decompensation in childhood asthma?

Acute exacerbation accounts for frequent and recurrent ER visits in children with asthma. Genetic susceptibility and interaction with factors such as infection/inflammation, exposure to environmental pollutants may contribute to acute decompensation. Predictive modeling using multiple data points including genetic variants, environmental exposure, and self monitored spirometry may help with early detection and intervention ...more »

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(@nmartin20)

AoU Research Priorities Use Cases

What are the benefits of using hypochlorous acid (HOCL) on skin conditions including vulvadynia, and yeast infections?

HOCL is currently used in hospitals as a wound care agent. Several promising research studies have been done to suggest this molecule can do more than we currently know. Now that it is readily available, trials on patients with vulvadynia and/or chronic yeast infections could be conducted to confirm its' healing properties for these specific conditions. It would be expected that patients would see noticeable symptom ...more »

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(@ostamp)

AoU Research Priorities Use Cases

How does the home environment impact asthma development in children?

This study would look at aspects of the home environment, including: cleaning products, address or block group for GIS mapping, proximity to roadways or certain agricultural or industrial facilities, pets, number of people living in the household, type of flooring, building structure, ventilation, type of heat, mold, and moisture level.

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(@rjguzman)

AoU Research Priorities Use Cases

Contribution of genetic, environmental, and dietary factors to peripheral atherosclerosis

Peripheral artery disease (PAD) affects about 13% of the population over 50 years and it is an important cause of morbidity and mortality. The ankle brachial index (ABI) is an inexpensive and non-invasive test used to screen for PAD, and an abnormal value is associated with increased cardiovascular events. Adding the collection of serial ABIs to the All of US database will allow for numerous future studies aimed at defining ...more »

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(@jjenkins45)

AoU Research Priorities Use Cases

What are the personal narratives of those receiving genetic test results (when available)?

Longitudinal narrative inquiry capturing diverse voices of study participants receiving genetic test results has the potential to fill gaps in the understanding of individual/family expectations; reactions; actions; and outcomes. Objectives: assess attitudes, literacy, perspectives about receiving genetic test results, implications of results for self/others, family communication pathways, and valued resources. Qualitative ...more »

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