(@mbl2018)

AoU Research Priorities Use Cases

What shapes perceptions of whether the healthcare system takes patient concerns seriously and how do they affect patient health?

Patients, like many of the 11.2% of Americans with chronic pain, can feel that providers do not take their health concerns seriously. The goals of this research are: 1. identify factors (e.g., race, gender, SES) that affect perceptions of how seriously the healthcare system takes the concerns of patients across a variety of conditions (e.g., fibromyalgia, lupus) and, 2. test how these perceptions affect patient health... more »

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(@mbl2018)

AoU Research Priorities Use Cases

How do mindsets about illness & treatment affect biomarkers of inflammation & treatment outcomes in patients w/ chronic illness?

Half of all Americans are diagnosed with one or more chronic illnesses, like heart disease and cancer. Mindsets about these illnesses may have a profound impact on the diagnosis, progression, and treatment of these illnesses. This study aims to: (1) understand the distribution of mindsets held by a diverse group of both healthy and chronically ill Americans, and (2) identify relationships between these mindsets, biomarkers... more »

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(@mbl2018)

AoU Research Priorities Use Cases

How do our mindsets about diet, exercise, and stress influence health behaviors and health outcomes?

Research has shown that benefits of health behaviors such as diet, exercise, and stress depend not just on the behaviors themselves but on the mindsets people have about those behaviors (Crum, Achor & Salovey, 2013; Zahrt & Crum 2017; Turnwald, Boles & Crum 2017); however, large-scale databases have not yet included measures of mindset. The goal of this study is to use validated measures of exercise, stress and diet mindsets... more »

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(@akanaya)

AoU Research Priorities Use Cases

What are the best diagnostic tests and thresholds for defining type 2 diabetes in Asian Americans?

Traditionally, occurrence of microvascular disease (retinopathy) has been used to define the glucose threshold by which diabetes should be defined. But these studies have come from mostly white/European/middle eastern populations. Do all ethnic groups have similar thresholds for diagnosis? Are certain diagnostic tests better for making the diagnosis of diabetes than others in select race/ethnic groups? The pathophysiology... more »

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(@jeanm5608)

AoU Research Priorities Use Cases

What barriers prevent people from volunteering as medical research subject?

To determine the barriers that prevent people from volunteering for medical research studies several questions need to be answered. The methods of advising people of studies for which they qualify need to be examined annually. The methods of reducing perceived risks for volunteering to participate in research should be examined. Successful methods of recruitment across the medical community need to be evaluated and... more »

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(@nih.health.econ.interest.group)

AoU Research Priorities Use Cases

How do different health conditions and treatments affect health-related quality of life? How do effects vary with other factors?

Health-related quality of life (HRQOL) is a common metric for individual and population health and for comparing outcomes across health conditions. Utility-based HRQOL measures are used to estimate Quality-Adjusted Life Years for cost-effectiveness and other studies. Including utility-based HRQOL in regular AOU data collections (baseline onward) will support myriad statistical, modeling, and evaluation studies by combining... more »

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(@judithjames808)

AoU Research Priorities Use Cases

Using AoU Big Data to decode factors which contribute to chronic back pain

Back pain is a common cause of disability in the US. All of Us provides a unique opportunity to assess measures of physical activity, diet, environmental factors, depression and coping skills on prevention of the transition of acute back pain to chronic back pain. Participants can be provided with exercise and health information regarding these conditions and the impact of racial/ethnic background on outcomes can be... more »

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(@judithjames808)

AoU Research Priorities Use Cases

Identification of at-risk individuals for autoimmune disease prevention and discovery of natural history

Autoimmune diseases afflict nearly 1 in 12 Americans and many more have autoantibodies but no evidence of clinical disease. Recent work has identified biomarkers or clinical symptoms which associate with subsequent developing development of systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) and NIH-funded prevention trials are underway. AoU provides a unique opportunity to identify at risk individuals through... more »

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(@judithjames808)

AoU Research Priorities Use Cases

What environmental and genetic factors influence the development of osteoarthritis?

Osteoarthritis (OA) is the most common cause of disability in the United States, and there are no available biomarkers or disease-modifying therapies for OA. Currently, we are unable to identify rapidly progressive OA patients at diagnosis. All of Us offers a unique opportunity to obtain clinical data and biospecimens, along with diet and exercise information, which associate with rapidly progressive OA to help foster... more »

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(@judithjames808)

AoU Research Priorities Use Cases

How do inflammation and subclinical autoimmunity impact adverse reproductive health?

Preterm delivery is a serious problem. SLE and RA patients have increased pregnancy morbidity before diagnosis and their healthy sisters have increased rates of pregnancy complications. Therefore, pre-clinical autoimmunity or inflammation may affect pregnancy outcomes. Reproductive and family history, and rheumatic disease symptoms, would be collected and correlated with hsCRP levels and autoantibody production in a... more »

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(@abaccarelli)

AoU Research Priorities Use Cases

Does the human epigenome reflect exposure to environmental chemicals?

The human epigenome is altered by environmental pollutants, including particulate air pollution, bisphenol A, phthalates, metals, pesticides, dioxin-like compounds, and persistent organic pollutants. All of us will be uniquely positioned to link exposure to environmental chemicals with alterations in the human epigenome. This will require refined measures of environmental exposure that—if measured in All of us—will cause... more »

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(@nhgri.divisionofgenomescience)

AoU Research Priorities Use Cases

Do genomic data provide clinically useful information beyond the data gathered during standard clinical care?

1. A cohort of people with WGS and pharmacogenomic data from blood sample. Randomize half of to get data in easily available tissues: DNA sequence (for somatic variants and mosaicism), RNA expression, and epigenomic data. Compare health outcomes between both groups.. 2. Assay all data types in a group and consider when genomics made a difference in their healthcare outcomes. For this approach we would need methods... more »

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