(@stacywheeler27)

AoU Research Priorities Use Cases

Can we create/replicate human IGA?

IGA is secreted in breast milk. Could this be a possible treatment method for those in which they have issues in organs where a lack of IGA may trigger disease bc IGA does play such a crucial role in the immune function of mucous membranes, and therefore a lack of puts those at risk. Goals-treat diseases by bringing body more into balance versus taking blocking inflammatory from signaling proteins.

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4 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What genetic and environmental risk factors contribute to the development of pelvic organ prolapse (POP) as females age?

This study will focus on the entire cohort (menarche through lifespan) to collect data on general health and wellbeing as well as detailed pregnancy & delivery histories. Activity level will be monitored, specifying any straining associated with either physical activity or occupation. Genetic/epigenetic factors, such as family history of POP or connective tissue disorders will be obtained, as will data on other currently... more »

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25 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What microbiome characteristics of children exposed to antibiotics and different diets influence long-term health outcomes?

Follow a subsample of all infants and children (< 3 years of age) throughout childhood to obtain the following serial assessments: blood tests, medication history, neonatal, infant and childhood health outcomes; physical measurements and laboratory microbiologic evaluations of oral, skin and vaginal specimens. Assessments and measures would be used along with health outcomes to determine associations and develop predictive... more »

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153 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What risk factors predispose children to sepsis, and what interventions are most effective for prevention and treatment?

This study will focus on the entire cohort of children (infants-18 y/o) and will identify those risk factors which predispose children to sepsis. The information will be used to create more precise strategies to identify individuals at highest risk of sepsis and to implement preventive or early treatment therapies that would improve outcomes. The study will also assess the use of adjunctive immunomodulatory therapies... more »

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35 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

How are sleep characteristics associated with pediatric developmental conditions, disorders or chronic disease?

This study will focus on the entire cohort (infant-19 y/o) to provide health and behavior outcomes associated with sleep characteristics, including environmental and demographic factors. This information will help better define the development of sleep, help develop more precise strategies to target children with sleep characteristics predictive of poor health outcomes, and develop more precise strategies for children... more »

Voting

94 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What genetic markers predict consequences of pregnancy associated hypertension & gestational diabetes for mothers & offspring?

This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.

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26 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What is the genetic architecture of neurodevelopmental problems and how does it relate to health disparities?

From a diverse sample of children in both clinical and non-clinical settings, investigate genetic contributions to a wide range of neurodevelopmental problems (NPs). Individual-variant and polygenic approaches can advance our understanding of the genetic overlap between, and specificity in, different types of NPs. In a large and diverse sample that includes different racial/ethnic and socioeconomic groups, these techniques... more »

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33 votes
Ideate
(@w.litchfield)

AoU Research Priorities Use Cases

What genetic, dietary, environmental and other factors are associated with and may cause sudden cardiac arrest?

Each year sudden cardiac arrest (SCA) strikes over 300,000 Americans, and ~90% die unless given CPR and/or an electric shock from an AED. While SCA is linked to some heart conditions, there is much to learn about the role of various genes, dietary factors, environmental toxins, some pharmaceuticals, and emotional stressors. It is recommended that a cohort of SCA survivors (with ICDs to prevent death) be included in... more »

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12 votes
Ideate

AoU Research Priorities Use Cases

Preconception predictors of preterm birth

Given the limited effects of current interventions to prevent preterm birth, it seems likely that the stage for adverse pregnancy outcomes is set even before the pregnancy begins. The All of Us cohort, if sufficient reproductive-aged women are enrolled, would be in a position to examine social, behavioral, medical, and biological/molecular predictors of preterm birth and its subtypes.

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17 votes
Ideate