Endomorphine is a highly selective mu but not delta or kappa receptors which cause all the unwanted side effects of opioids. Goals - Prove Endomorphin's superiority to other opioids. Methods - Monitor pain levels, addiction through tox screens and mortality rates from overdose. Expected outcome - Endomorphin will have very low if any overdoses, tolerance build up should be minimal, alcohol addiction should be reduced,... more »
The fundamental question in addiction research is why some people become addicted while others who are exposed abused substances do not. There is an opportunity to answer this question for opioid addiction and respiratory depression in surgical patients. About 5 to 10 percent of surgical patients who are pain free and opioid naïve, given opioids during and after surgery, persist in opioid use 12 months after surgery... more »
Alcohol use disorder (AUD) is a common problem with a significant public health impact. Despite available treatments of various types, fewer than 10% of individuals diagnosed with an AUD receive specific treatment for this disease. Identifying the factors that prevent individuals from seeking treatment could better improve access to treatment, thereby eliminating disease burden.