More than 1 in 5 Americans meet lifetime criteria for alcohol use disorder and 1 in 10 Americans meet lifetime criteria for a drug use disorder. Most individuals never seek treatment and most reduce their alcohol or drug use in the absence of treatment. Research on the biological, psychological, and social risk factors for developing and recovering from alcohol/drug use disorders is critical. Annual assessments of DNAm,... more »
Endomorphine is a highly selective mu but not delta or kappa receptors which cause all the unwanted side effects of opioids. Goals - Prove Endomorphin's superiority to other opioids. Methods - Monitor pain levels, addiction through tox screens and mortality rates from overdose. Expected outcome - Endomorphin will have very low if any overdoses, tolerance build up should be minimal, alcohol addiction should be reduced,... more »
If you offer 100 people $50 today or $60 in two months, some will choose the smaller reward now, others will choose the larger reward later. The way people evaluate current versus future rewards is partially genetic and has broad implications for a variety of health outcomes. We have already published on this paradigm (https://www.nature.com/articles/s41593-017-0032-x) but much more data is needed, ideally in subject... more »
Alcohol use disorder (AUD) is a common problem with a significant public health impact. Despite available treatments of various types, fewer than 10% of individuals diagnosed with an AUD receive specific treatment for this disease. Identifying the factors that prevent individuals from seeking treatment could better improve access to treatment, thereby eliminating disease burden.