(@ostamp)

AoU Research Priorities Use Cases

How does the home environment impact asthma development in children?

This study would look at aspects of the home environment, including: cleaning products, address or block group for GIS mapping, proximity to roadways or certain agricultural or industrial facilities, pets, number of people living in the household, type of flooring, building structure, ventilation, type of heat, mold, and moisture level.

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0 votes
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(@rvandlik)

AoU Research Priorities Use Cases

1. Define phenotypes/endotypes of asthma based on clinical and patient reported data, and determine if any specific therapies a

Using clinical information obtained from patients (types of symptoms, severity of symptoms, exercise-related symptoms, day versus night symptoms, prednisone use, hospitalization, ED visit, etc.), determine if there is a relationship between these patient reported symptoms and clinical data (FEV1, FeNO, peak flow, O2 saturation, etc.).

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2 votes
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(@rvandlik)

AoU Research Priorities Use Cases

1. Define phenotypes/endotypes of asthma based on clinical and patient reported data, and determine if any specific therapies a

Using clinical information obtained from patients (types of symptoms, severity of symptoms, exercise-related symptoms, day versus night symptoms, prednisone use, hospitalization, ED visit, etc.), determine if there is a relationship between these patient reported symptoms and clinical data (FEV1, FeNO, peak flow, O2 saturation, etc.).

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2 votes
Ideate

AoU Research Priorities Use Cases

AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and ...more »

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1 vote
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AoU Research Priorities Use Cases

What factors contribute to the disparate respiratory (and cardiovascular) outcomes of infants born prematurely?

Infants born at <28 weeks of gestation who survive can experience long-term impacts from subtle abnormalities in respiratory function to profound disability including asthma, early COPD, or long-term dependence on mechanical ventilation. It is unclear how maternal environmental exposures, geographic differences, social factors, or genetic predisposition in the pre-conceptional period or during pregnancy might contribute ...more »

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4 votes
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(@niehsextramural)

AoU Research Priorities Use Cases

How environmental chemicals mediate/influence comorbid chronic diseases?

Two of the greatest public health challenges facing the US today are obesity and asthma. These two comorbid conditions are also implicated in downstream disorders such as diabetes and CVD. There is evidence that environmental exposures contribute to a rapid increase in disease incidence. Using the AoU cohort to understand how environmental exposures exacerbate the cormbidity between these conditions and subsequent disease ...more »

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15 votes
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(@jpcastner15)

AoU Research Priorities Use Cases

What are the multi-level, immune-mediated, environmental exposure endotype pathways of environmental illness? Asthma/allergies?

Focusing recruitment on communities with a disproportionate burden of environmental exposure (such as Western New York), develop and test a multi-level model to ascertain the burden of environmental illness symptom clusters, asthma, and allergies attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden 5) inflammatory biomarker response levels over time. ...more »

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5 votes
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(@samfriedman)

AoU Research Priorities Use Cases

How do metropolitan-level factors, including residential segregation, shape pediatric and/or adult asthma?

The prevalence of asthma is on the rise and is high for racial minorities. No attention has been paid to the impact of the variation in metropolitan-level characteristics on asthma largely because of limited metropolitan variation in available data. Metropolitan-level residential segregation affects minority housing, and housing conditions are an important determinant of asthma. The All of Us project should collect asthma ...more »

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6 votes
Ideate
(@jconstible)

AoU Research Priorities Use Cases

Do residential energy efficiency measures improve physical and mental health?

Goal: Identify and quantify health benefits of energy efficiency measures in single- or multi-family housing. Data tools: Resident surveys, air pollution monitors, temperature monitors, energy usage data from electric utilities. Expected outcomes: Previous qualitative and quantitative work suggests residents of more energy efficient homes experience fewer cardiovascular symptoms (e.g., asthma attacks) and fewer exposures ...more »

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9 votes
Ideate
(@klosecall)

AoU Research Priorities Use Cases

Can pollen allergies be isolated by genetics, confirmed by allergy testing, and exposure be tracked to limit asthma attacks?

A cohort of asthma patients (who believe they have a pollen allergy) would undergo genetic testing to identify genetic markers. Those patients would undergo blood and skin allergy testing to confirm the allergy, and then the patients would be utilize a mobile monitor to track the weather and environmental exposures (esp. pollen) that are causal to asthma incidences. With a more complete picture of pollen allergen impacts ...more »

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39 votes
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(@westrw)

AoU Research Priorities Use Cases

What GENE(S) is responsible for HYPERSENSITIVITY to inhaled corticosteroids in Asthma patients, and how does it function?

1) Bin asthma patients for hypersensitivity to inhaled corticosteroids (hypersensitivity- "dose dependent slow but steady strangulation"). Improvement may be determined simultaneously, allowing complete characterization of response to treatment, according to drug, dosage, duration of treatment, etc. While this study is limited to inhaled corticosteroids, other drug treatments may be performed similarly. 2) Determine ...more »

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8 votes
Ideate
(@westrw)

AoU Research Priorities Use Cases

What GENE(S) is responsible for HYPERSENSITIVITY to inhaled corticosteroids in Asthma patients, and how does it function?

1) Bin asthma patients for hypersensitivity to inhaled corticosteroids (hypersensitivity- "dose dependent slow but steady strangulation"). Improvement may be determined simultaneously, allowing complete characterization of response to treatment, according to drug, dosage, duration of treatment, etc. While this study is limited to inhaled corticosteroids, other drug treatments may be performed similarly. 2) Determine ...more »

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8 votes
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