(@svogelstein)

AoU Research Priorities Use Cases

Are pesticides associated with cancer risk?

Pesticides are commonly used inside and outside the home. Evidence from studies of farmers suggests that some pesticides are likely carcinogenic, but the impact of lower levels of exposure is less clear. By collecting information on pesticide exposure through surveys and analysis of carpet dust, we could evaluate the risk of cancer associated with low levels of pesticide exposure. Given their widespread use, even a small... more »

Voting

4 votes
Ideate
(@svogelstein)

AoU Research Priorities Use Cases

Are pesticides associated with cancer risk?

Pesticides are commonly used inside and outside the home. Evidence from studies of farmers suggests that some pesticides are likely carcinogenic, but the impact of lower levels of exposure is less clear. By collecting information on pesticide exposure through surveys and analysis of carpet dust, we could evaluate the risk of cancer associated with low levels of pesticide exposure. Given their widespread use, even a small... more »

Voting

4 votes
Ideate
(@svogelstein)

AoU Research Priorities Use Cases

What are the long-term health effects of using hair dyes?

Hair dyes are commonly used in today‚Äôs society, but the long-term health effects are not known. Many hair dyes contain chemicals that are thought to be potentially carcinogenic. Studies have suggested that hair dying may be associated with an increased risk of lymphoma and possibly breast cancer; however, few prospective studies have been conducted. Given the extensive use of hair dyes, particularly among women, even... more »

Voting

2 votes
Ideate
(@svogelstein)

AoU Research Priorities Use Cases

What is the long-term impact of consumption of organic foods on health outcomes?

Organic foods are thought to be healthier than conventional foods because of the limited exposure to pesticides and other chemicals. Few studies have examined the long-term health effects of organic foods. By collecting information on organic food consumption and comparing those who tend to consume more organic foods (e.g., organic fruits/veg) to those who consume less, we could evaluate the impact of organic food consumption... more »

Voting

11 votes
Ideate
(@renaissance)

AoU Research Priorities Use Cases

How reliably do epigenetic aging clocks predict disease onset and mortality? Can they be slowed or reversed?

An annual blood test with analysis of methylation sites from key epigenetic aging clocks (e.g. Horvath). Epigenetic aging clocks have already been shown to reliably predict age, time-to-death, all cause mortality, cog. function, immune function, CV disease, cancer, and more. They may also become a key tool to demonstrate the reversibility of disease risk through dietary and therapeutic regimens, as epigenetic states are... more »

Voting

35 votes
Ideate
(@renaissance)

AoU Research Priorities Use Cases

How reliably do epigenetic aging clocks predict disease onset and mortality? Can they be slowed or reversed?

An annual blood test with analysis of methylation sites from key epigenetic aging clocks (e.g. Horvath). Epigenetic aging clocks have already been shown to reliably predict age, time-to-death, all cause mortality, cog. function, immune function, CV disease, cancer, and more. They may also become a key tool to demonstrate the reversibility of disease risk through dietary and therapeutic regimens, as epigenetic states are... more »

Voting

35 votes
Ideate
(@craigoj)

AoU Research Priorities Use Cases

Are there diagnostic/prognostic biomarkers for cancer antigens within large random libraries of non-biological molecular shapes?

We developed a robust method to synthesize molecular libraries of non-biological molecular shapes (10^8 variant molecules) and then down-select individual ligands for diagnostics of disease states. We successfully applied the method to infectious and auto-immune diseases, and have explored the utility of tumor-associated antigens (TAA) and TAA antibodies as cancer biomarkers. We propose to use our innovative method as... more »

Voting

1 vote
Ideate
(@riscutag2)

AoU Research Priorities Use Cases

Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

Voting

19 votes
Ideate
(@riscutag2)

AoU Research Priorities Use Cases

Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

Voting

19 votes
Ideate
(@gadallas)

AoU Research Priorities Use Cases

Can we build precise cancer risk prediction models that may guide early diagnosis

The early detection of cancer improved treatment outcomes and patient survival. Building precise risk prediction models can personalize cancer screening programs to ones need. The integration of variables capturing changes in lifestyle factors, exposure history, and molecular markers overtime, together with the opportunity for passive surveillance through data linkage to electronic medical records and cancer registries... more »

Voting

6 votes
Ideate
(@changhu)

AoU Research Priorities Use Cases

What are the long-term cardiovascular effects of cancer therapy? Do childhood cancer survivors have reduced cardiac functions?

To study adult cancer survivors who received cancer therapy during childhood. What are their cardiovascular functions as compared to adults who did not receive cancer therapy. Reduction of cardiovascular functions after anticancer therapy may take years to develop. These undesirable complications can compromise quality of life or shorten life span. This study will provide evidence-based guidelines for physicians to choose... more »

Voting

17 votes
Ideate
(@changhu)

AoU Research Priorities Use Cases

Cancer and clot: What is the incidence and timing of thromboembolism after cancer diagnosis

Conduct research to understand the epidemiology of thromboembolism after cancer diagnosis and identify the contributing factors. Thromboembolism can cause treatment dilemma as many anticancer treatments cause thrombocytopenia. Better understanding of the timing and risk factors can provide evidence-based management of cancer patients without the risks of life threatening bleeding or thromboembolism. Possible risk factors... more »

Voting

1 vote
Ideate
(@lilitm)

AoU Research Priorities Use Cases

What treatments can be adopted from similar mutations and adenocarcinomas to urgently treat advanced Gallbladder Cancer?

GBC is the most common biliary cancer, most often symptomless until metastasized. Young and otherwise healthy people are getting shocking stage 4 GBC diagnoses, only to be told that there are no treatment options besides one palliative protocol of debilitating chemotherapy. We need a clinical trial that carefully considers the specifics of advanced GBC patients and urgently applies strategies from related mutations (KRAS... more »

Voting

3 votes
Ideate
(@junseok.chae)

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Help Identify People with Cardiovascular Disease

We will use non-invasive wearable monitoring sensors, similar to a band-aid on the wrist, that measure arterial wave forms at the radial artery in the wrist, providing information on the elasticity and function of cardiovascular system. The information will be uploaded to smartphones and correlated with age and known cardiovascular risk factors, allowing to develop computational models to rapidly identify people at risk... more »

Voting

3 votes
Ideate
(@changhu)

AoU Research Priorities Use Cases

What are the genetic, comorbid risk factors, and anticancer agents that contribute to heart failure after cancer therapy

Goals:To study the epidemiology of cardiovascular complications of cancer therapy in order to design prevention strategy and precision treatment of cancer patients while minimizing debilitating cardiovascular complications. Methods: compare data on genetic, co morbid risk factors, and anticancer agents used in association with cardiovascular complications after cancer therapy. Expected outcomes: This study will provide... more »

Voting

11 votes
Ideate