Showing 21 ideas for tag "cardiovascular"
(@pnatarajan) kudos icon +

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How do environmental exposures, behavior, & genetics, in combination, influence risk of atherosclerotic cardiovascular disease.

Genetics can be the earlier risk predictor of common, heritable traits such as atherosclerotic cardiovascular disease (ASCVD). Longitudinal environmental exposures and behavioral practices subsequently modify risk. Uniform dense ascertainment of environmental exposures and behavior is feasible through wearable sensors. We and others are beginning to look at the comprehensive set of exposures that influence ASCVD risk.... more »

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12 votes
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(@renaissance) kudos icon +

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How reliably do epigenetic aging clocks predict disease onset and mortality? Can they be slowed or reversed?

An annual blood test with analysis of methylation sites from key epigenetic aging clocks (e.g. Horvath). Epigenetic aging clocks have already been shown to reliably predict age, time-to-death, all cause mortality, cog. function, immune function, CV disease, cancer, and more. They may also become a key tool to demonstrate the reversibility of disease risk through dietary and therapeutic regimens, as epigenetic states are... more »

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35 votes
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(@wye000) kudos icon +

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What is the long-term comparative effectiveness of empagliflozin in a heterogeneous population with type 2 diabetes?

Empaglifozin, a highly selective sodium-glucose cotransport 2 (SGLT2) inhibitor, has been shown to significantly reduce major adverse cardiovascular (CV) events and hospitalization for heart failure in patients with type 2 diabetes (T2DM) and established CV disease. The generalizability of this finding to lower risk population is unknown. We propose to compare cardiovascular outcomes in a more heterogeneous population... more »

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3 votes
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(@jenna.norton) kudos icon +

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Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

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7 votes
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(@ginawei) kudos icon +

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Common trajectories of body mass index (BMI) across the lifespan and their differential impact on cardiovascular diseases

Following AoU participants for decades could uncover common trajectories of body mass index (BMI) across lifespan and their associations/impact on cardiovascular diseases (CVD). AoU’s size/diversity also enables precise measure of the associations by different subgroups (e.g., race, sex, social factors, presence of multiple risk factors). The findings could further shed light on optimal timing for initiating and/or intensifying... more »

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16 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Common blood pressure (BP) trajectories across the lifespan and their impact on cardiovascular diseases

Following AoU participants for decades could uncover common trajectories of BP across lifespan and their associations/impact on cardiovascular diseases (CVD). AoU’s size/diversity also enables precise measure of the associations by different subgroups (e.g., race, sex, social factors, presence of multiple risk factors). This could lead to refined risk predictions for CVD and further shed light on optimal timing for initiating... more »

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7 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Why are some people with multiple cardiovascular risk factors resilient against developing cardiovascular diseases?

People who smoke or have hypertension, diabetes, and hyperlipidemia are at increased risk of developing cardiovascular diseases (CVD). However, not all do, and it would be interesting to identify those with CVD risk factors but remain free of CVD. Studying these people phenotypically, genomically, environmentally, and molecularly (via -omics) could provide great insight into novel mechanisms by which new treatments... more »

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13 votes
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(@ginawei) kudos icon +

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The association of cardiovascular risk factors on the development of vascular dementia

Recent findings from 15,744 black and white adults in the ARIC Cohort Study found that several cardiovascular (CV) risk factors in middle age (smoking, diabetes, prehypertension & hypertension) are linked to higher risk of dementia later in life, and that blacks have higher rates of dementia v. whites. AoU offers ability to evaluate differential associations of specific CV risk factors, & their interactions with other... more »

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12 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Develop more accurate and clinically relevant sub-classification/phenotyping of heart failure

Heart failure (HF), though relatively common in U.S. adults, can be thought of as a syndrome with many subtypes that require different treatments. All of Us provides a rich platform on which to collect more data (e.g., novel biomarkers and imaging studies) on HF patients. This, coupled with AoU’s existing rich genomics, behavioral, and clinical data, can be analyzed to refine the phenotyping and sub-classification of... more »

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9 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Identify and create a cohort of heart failure patients within All of Us to enable discovery and clinical research

Prevalence of heart failure (HF) in U.S. has risen to ~6.1 million among those ≥20 years of age. AoU provides a rich platform to identify HF patients through EHR (including clinical laboratory and imaging reports) and claims data. Ability to follow and collect data prospectively in the patients, including ancillary studies of more surveys and imaging/biomarker collections, could advance discovery science and address... more »

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9 votes
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(@steffleonard) kudos icon +

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How do maternal health complications affect the long-term health of women and outcomes in subsequent pregnancies?

Severe maternal morbidities are rare, but increasing in the U.S., and the causes and long-term consequences are poorly understood. All of Us would provide a study population with enough participants, detail, and follow-up time to thoroughly investigate how complications during pregnancy, delivery, and postpartum affect future health in women and their children to inform prevention of negative outcomes, such as cardiovascular... more »

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16 votes
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(@ginawei) kudos icon +

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In elderly with stable obstructive coronary disease, what factors predict long-term stability w/ medical management alone?

The number of elderly with heart disease is growing. AoU can address key questions by following the clinical management and outcome of these patients – e.g., among elderly patients with recently diagnosed chronic stable obstructive coronary disease, what factors (comorbidity, genomics, socio/environmental, behavioral) predict long-term stability with medical management alone vs. coronary revascularizations? And how does... more »

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3 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

What are the impact of common environmental exposures on cardiovascular (CV) and other health outcomes?

We are constantly exposed to environmental exposures such as air pollution, allergens, and man-made chemicals. AoU offers a unique opportunity to collect such exposures both passively (e.g., linking to local environmental data) and actively (e.g., using novel mHealth devices to measure new data from individual AoU participants). These can be overlaid with behavioral, clinical, genomics, and biological data in AoU to assess... more »

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19 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

How well do the ACC/AHA Atherosclerotic Cardiovascular Disease (ASCVD) risk scores work in Asian Americans?

The ASCVD risk scores was introduced by American College of Cardiology (ACC) & American Heart Association (AHA) in 2013 to provide 10-year risk for use in Blood Cholesterol Guideline. Absence of Asian Americans in the cohorts that provided the data for developing the scores may limit its precision in these individuals. AoU offers unique opportunity to collect CVD risk factors & outcomes in Asian Americans and its heterogeneous... more »

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9 votes
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(@ginawei) kudos icon +

AoU Research Priorities Use Cases

Toward a more precise risk prediction for ischemic stroke in Asians Americans with Atrial Fibrillation (AF)

Research in Asia vs. findings in U.S. suggest risk of ischemic stroke AND bleeding with oral anticoagulant may be higher in East Asian vs. non-Asian AF patients. However, data is lacking in Asians living in the U.S. With its diversity goal, AoU is expected to recruit substantive number of Asian Americans. AoU can be leveraged to see whether this finding extends to Asian Americans, who have different exposures (behavioral,... more »

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6 votes
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