(@niehsextramural)

AoU Research Priorities Use Cases

How environmental chemicals mediate/influence comorbid chronic diseases?

Two of the greatest public health challenges facing the US today are obesity and asthma. These two comorbid conditions are also implicated in downstream disorders such as diabetes and CVD. There is evidence that environmental exposures contribute to a rapid increase in disease incidence. Using the AoU cohort to understand how environmental exposures exacerbate the cormbidity between these conditions and subsequent disease... more »

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15 votes
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(@jenna.norton)

AoU Research Priorities Use Cases

Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

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7 votes
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(@jenna.norton)

AoU Research Priorities Use Cases

Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

Voting

7 votes
Ideate
(@cavin.ward)

AoU Research Priorities Use Cases

Does adding environmental exposures at the primary residence to cardiovascular risk scores improve risk prediction?

The American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease risk score is a well-known and widely used risk score that provides 10-year risk estimates. However, this score does not account for environmental exposures as experienced at a person's primary residence, many of which are strongly associated with cardiovascular disease. Using All of Us we can evaluate if measurements... more »

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3 votes
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