(@trlewis)

AoU Research Priorities Use Cases

Are teenagers who were exposed to SSRIs in utero more likely to experience psychiatric illnesses than those who were not exposed

Up to 8% of pregnant women take an antidepressant, but we do not understand the long-term effects on brain development and childhood mental illness. A cohort of young adults (16-21) would be assessed for psychiatric illness, in utero medication exposure would be recorded (with emphasis on antidepressants) and potential confounders such as intellectual/physical disability, adverse childhood experiences, family hx, etc... more »

Voting

18 votes
Ideate
(@jsmoller)

AoU Research Priorities Use Cases

How can we predict and prevent suicide and suicidal behavior?

Suicide is a leading cause of death and rates have not decreased in decades. Currently there are no established risk factors that have demonstrated usefulness in predicting individual risk. The All of Us program is in a position to change this by leveraging the large and varied data that will be collected. Making progress in this area would be a major advance and could have a tremendous impact on the suffering that individuals... more »

Voting

28 votes
Ideate
(@jsmoller)

AoU Research Priorities Use Cases

How can we predict and prevent suicide and suicidal behavior?

Suicide is a leading cause of death and rates have not decreased in decades. Currently there are no established risk factors that have demonstrated usefulness in predicting individual risk. The All of Us program is in a position to change this by leveraging the large and varied data that will be collected. Making progress in this area would be a major advance and could have a tremendous impact on the suffering that individuals... more »

Voting

28 votes
Ideate
(@mara.mather)

AoU Research Priorities Use Cases

What health factors relate to positive and negative emotional bias?

When two faces are presented simultaneously, depressed people show a bias to look at the face with a negative expression. In contrast, older adults tend to look away from faces with negative expressions, consistent with the positivity effect seen in healthy older adults and their generally reduced negative affect. Little is known about how health helps shape these emotional biases. We also don't know how these biases... more »

Voting

14 votes
Ideate
(@mara.mather)

AoU Research Priorities Use Cases

What health factors relate to positive and negative emotional bias?

When two faces are presented simultaneously, depressed people show a bias to look at the face with a negative expression. In contrast, older adults tend to look away from faces with negative expressions, consistent with the positivity effect seen in healthy older adults and their generally reduced negative affect. Little is known about how health helps shape these emotional biases. We also don't know how these biases... more »

Voting

14 votes
Ideate
(@rebeheart)

AoU Research Priorities Use Cases

Are different depression phenotypes associated with different prognosis after myocardial infarction (MI)?

Are there depression (MDD) phenotypes that have different genomic, biological, and psychological underpinnings, which we should be treating differently? Utilize an acute post-MI sample stratified by non-MDD, prior history of MDD, or new MDD. Then stratify all MDD by treated-success-MDD, treatment-resistant depression, and not treated. Examine mortality and cardiovascular event recurrence among non-MDD and MDD types,... more »

Voting

10 votes
Ideate
(@sjogrens.syndrome.foundation)

AoU Research Priorities Use Cases

How can we better understand fatigue, depression, and cognitive dysfunction in Sjögren's and other autoimmune diseases?

Autoimmune diseases, such as Sjögren's, manifest themselves in a wide variety of ways in patients. However, a common thread in many of these diseases is fatigue, depression, and cognitive dysfuction, or "brain fog." These physical and mental manifestations can have serious, debilitating, consequences for those who suffer with them. A better understanding of the pathways of these manifestations will allow for a more informed... more »

Voting

33 votes
Ideate
(@sjogrens.syndrome.foundation)

AoU Research Priorities Use Cases

How can we better understand fatigue, depression, and cognitive dysfunction in Sjögren's and other autoimmune diseases?

Autoimmune diseases, such as Sjögren's, manifest themselves in a wide variety of ways in patients. However, a common thread in many of these diseases is fatigue, depression, and cognitive dysfuction, or "brain fog." These physical and mental manifestations can have serious, debilitating, consequences for those who suffer with them. A better understanding of the pathways of these manifestations will allow for a more informed... more »

Voting

33 votes
Ideate
(@margit)

AoU Research Priorities Use Cases

Interaction between diet, sleep, alcohol use, stress genetics and depression risk

Cardiovascular disease and depression are associated, but direction is unclear - or both (heart attack is a stressor triggering depression, depression leads to less exercise and increases CVD). Sleep disturbance is associated with alcohol and depression - cause and effect unclear. Alcohol can increase depression risk, and vice versa. Increasing omega-3 vs. omega-6 may be preventive for both depression and CVD. AOU is... more »

Voting

41 votes
Ideate
(@pam.lovera)

AoU Research Priorities Use Cases

Do individuals with diagnosed depression have a higher incidence of methylenetetrahydrofolate reductase (MTHFR) mutation?

Looking at individuals with diagnosed depression (any duration), is there a higher incidence of MTHFR mutations then in the general population. Methods would include offering a genetic test via cheek swab to look for MTHFR mutations MTHFR mutation has been linked to depression but is not routinely tested for. If a mutation is found, a prescription for L-methyl folate can potentially alleviate depressive symptoms rapidly... more »

Voting

10 votes
Ideate
(@acaple07)

AoU Research Priorities Use Cases

Could regular screening for postpartum for up to a year after birth decrease postpartum depression?

I would select women who has just given birth or have children ranging from 3 months, 6 months, and 9 months to get a postpartum screening done every three months to see if they have any signs of postpartum. The outcome is to see what and how the mother is feeling in the different milestones of the child's life as well as their own. What effects does it have on both the mother and the child

Voting

57 votes
Ideate
(@alan.sanders.md)

AoU Research Priorities Use Cases

Which genetic and environmental factors contribute to sexual orientation, and related health conditions?

Gays, lesbians, and bisexuals are underrepresented in biomedical research. While much relevant data is already planned for collection by AllofUs, additional or elaborated measures (see "data items") would help in seeking new leads and advancing work on pre-existing questions in the field. These items include sociodemographic (e.g., trait information), clinical (various associated conditions), and biological (genomic,... more »

Voting

30 votes
Ideate
(@fsc001)

AoU Research Priorities Use Cases

How does having lesions in the frontal lobe of the brain affect the mental health of a Multiple Sclerosis patient?

MRI studies would be performed with each MS flare and annually. Patients with lesions in their frontal lobe would complete a questionnaire regarding their mental and emotional state. Caregivers would also complete the questionnaire with their observations of the MS patient. We would expect to see mood disorders and/or depression in MS patients who have lesions in their frontal lobe. Data would be collected for 5 years.... more »

Voting

9 votes
Ideate