(@mpollard)

AoU Research Priorities Use Cases

Criteria for Environmental Associated Autoimmune Diseases

Goal: Survey patients with autoimmune diseases for information on occupational and other life style exposures to factors associated with autoimmunity (smoking, silica dust, solvents, etc). Build data bases containing clinical parameters, blood tests, and exposure data to help identify putative diagnostic criteria. Compare with patients having idiopathic autoimmunity (i.e. lacking known risk exposures)

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(@cwilliams)

AoU Research Priorities Use Cases

What are the determinate of successful treatment for Lyme disease

Diagnostic uncertainty, diffuse symptoms and a failure to notice tick bites (especially when bitten by larvae or nymphs) complicate ID of early disease. Early disease can be effectively treated with short course doxycycline but late stage is more difficult. A licensed vaccine was pulled due to low uptake in part because there was a suggestion that some HLA subtypes developed RA. Gaps exist in Lyme epidemiology necessary... more »

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