(@craigoj)

AoU Research Priorities Use Cases

Are there diagnostic/prognostic biomarkers for cancer antigens within large random libraries of non-biological molecular shapes?

We developed a robust method to synthesize molecular libraries of non-biological molecular shapes (10^8 variant molecules) and then down-select individual ligands for diagnostics of disease states. We successfully applied the method to infectious and auto-immune diseases, and have explored the utility of tumor-associated antigens (TAA) and TAA antibodies as cancer biomarkers. We propose to use our innovative method as... more »

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1 vote
Ideate
(@idsociety)

AoU Research Priorities Use Cases

Improving precision management of acute infections and sepsis as a major burden to healthcare systems

Key areas of unmet medical need: - Improve identification of patients at high risk for sepsis - Improve characterization of patients with sepsis (endotyping) - Predict outcomes of acute infections and/or sepsis at the time of presentation - Develop companion diagnostics (biomarkers?) that identify patients responding to specific sepsis therapies - Improve early diagnosis of pathogens causing sepsis and their resistance... more »

Voting

23 votes
Ideate
(@idsociety)

AoU Research Priorities Use Cases

Improving precision management of acute infections and sepsis as a major burden to healthcare systems

Key areas of unmet medical need: - Improve identification of patients at high risk for sepsis - Improve characterization of patients with sepsis (endotyping) - Predict outcomes of acute infections and/or sepsis at the time of presentation - Develop companion diagnostics (biomarkers?) that identify patients responding to specific sepsis therapies - Improve early diagnosis of pathogens causing sepsis and their resistance... more »

Voting

23 votes
Ideate
(@alexandra.boukhvalova)

AoU Research Priorities Use Cases

Differentiating healthy neurological aging from incipient nervous system dysfunction using smartphone apps.

Neurons are mostly non-renewing cells and neurodegenerative diseases are often diagnosed after many already died. This severely limits therapeutic efficacy. We propose accurate, convenient measures of broad neurological functions using developed smartphone apps to test whether derived subject-specific progression slopes can differentiate healthy aging from incipient neurological dysfunction. Such analysis may eventually... more »

Voting

24 votes
Ideate
(@sjogrens.syndrome.foundation)

AoU Research Priorities Use Cases

Can we identify and/or develop better diagnostic tools for Sjögren's and other autoimmune diseases?

For Sjögren's, and other autoimmune diseases, a lack of reliable diagnostic tools makes an accurate and timely diagnosis difficult. This, of course, is detrimental to the patient and delays the appropriate care being received. This study would focus on the identification and development of better diagnostic tools for autoimmune diseases, such as Sjögren's, which could then result in more timely and accurate diagnoses... more »

Voting

27 votes
Ideate
(@drirene)

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health. Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »

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219 votes
Ideate