(@lisa.signorello)

AoU Research Priorities Use Cases

To what extent are adverse childhood experiences (ACE) or trauma related to a wide range of adult diseases or premature death?

Adverse childhood experiences (ACE) can be retrospectively assessed in adults, ideally before the onset of the diseases under study. There are existing ACE instruments, or attempts to refine these instruments could be undertaken within All of Us.

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5 votes
Ideate
(@lisa.signorello)

AoU Research Priorities Use Cases

To develop or optimize a non-invasive BIOMARKER that can be used to measure the experience of stress in children and adults.

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

Voting

3 votes
Ideate

AoU Research Priorities Use Cases

Can the recycling of influenza viruses explain changes in phenotypes of CHD cases?

I proposed that the 1950s-60s CHD deaths were associated with H1-H2 Influenza A re-infectiosn of H3 Influenza primed individuals (born around 1890). After 1968, when the H3 influenza virus returned, high serum cholesterol CHD cases declined and a second atherogenic phenotype emerged (H3 re-infection of H1-primed cohorts born after 1900 and more after 1918?). Would CHD mortality with high serum cholesterol levels increase... more »

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1 vote
Ideate
(@jaime.gahche)

AoU Research Priorities Use Cases

Why assess diet and dietary supplements in the population?

Over half of US adults and one-third of children take at least one dietary supplement. Combined with intakes of foods, total nutrient intake can be estimated and linked to health outcomes in etiologic research. Such population data can inform guidance, such as the Dietary Guidelines for Americans and Dietary Reference Intakes. Supplements may be warranted for sub-groups where nutritional requirements may not be met through... more »

Voting

5 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

Voting

7 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

Voting

7 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

What characteristics are associated with urinary stone recurrence in persons with prior episode of urinary stone disease?

Urinary stone disease is burdensome and costly, and frequently recurs. Via the EHR and qualitative/quantitative methods, we will identify person and intervention characteristics associated with urinary stone recurrence. Factors associated with recurrence may provide potential treatment targets for preventing stone recurrence.

Voting

11 votes
Ideate
(@sehughes)

AoU Research Priorities Use Cases

What are the common threads between autoimmune diseases and what do people with autoimmune diseases have in common?

Goal - Survey patients with Celiac Disease, Hashimotos and other autoimmune diseases to evaluate lifestyle, environment, food, antibiotics, and previous stomach viruses to see what has triggered the onset of various autoimmune diseases. Is the similarity of the molecules that the body attacks significant (ex- thyroid and gluten)? If left unaddressed more autoimmune diseases can develop. What do people with autoimmune... more »

Voting

17 votes
Ideate
(@devacharya)

AoU Research Priorities Use Cases

In DISH calcifications, what causes ligaments to ossify and how can we further expand treatment given that information?

Findings answers may not only open doors to relieving the pain and misery of this disease but also for many other related diseases. Research needs to be done to develop improved treatment options, and perhaps animal models can be used to understand mechanisms and to test new medicines. Outcomes from such research can lead to new therapies and methods to reverse the condition and the at least, halt the progression of... more »

Voting

1 vote
Ideate
(@devimol)

AoU Research Priorities Use Cases

What are key communication gaps in chronic kidney disease care between physicians and patients who belong to underserved groups?

This would be a mixed methods study. The qualitative section would involve interviews to ascertain gaps in in chronic kidney disease communication (likely risk assessment in CKD progression, information about dialysis options, mental health, advance care planning). This would be followed by surveys of patient-reported measures of communication, such as CAT (Communication Assessment Tool; https://www.ncbi.nlm.nih.gov/pubmed/17574367).... more »

Voting

9 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

What characteristics are associated with maintenance of increased water intake in persons with urinary stone disease?

Increased water intake reduces stone recurrence, but maintaining increased intake is challenging. Via the EHR and qualitative/quantitative methods, we will identify person and intervention characteristics associated with maintenance of increased intake to determine factors that facilitate intervention success and/or enable targeted interventions. Findings may provide insights into strategies for maintenance of behavior... more »

Voting

11 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

What characteristics are associated with maintenance of increased water intake in persons with urinary stone disease?

Increased water intake reduces stone recurrence, but maintaining increased intake is challenging. Via the EHR and qualitative/quantitative methods, we will identify person and intervention characteristics associated with maintenance of increased intake to determine factors that facilitate intervention success and/or enable targeted interventions. Findings may provide insights into strategies for maintenance of behavior... more »

Voting

11 votes
Ideate
(@greg.buchold)

AoU Research Priorities Use Cases

What disease risk variants are unique to naturalized citizens of recent African origin and enriched in African-Americans?

To better understand variants relevant to African-Americans and their disease risk it would be helpful to have data on reference African populations from the African ethnic groups with the greatest historical genetic contribution through the transatlantic slave trade. Naturalized U.S. citizens born in Africa would be more easily accessible to regional sequencing leaders (e.g. Houston has the largest Nigerian U.S. population... more »

Voting

1 vote
Ideate
(@raodiv)

AoU Research Priorities Use Cases

Role of Persistent Co-infections in Health and Disease

Co-infections can significantly alter disease risk, incidence, prevalence, aggressiveness, treatment response and outcomes, in addition to, making it more difficult to manage and treat the diseases. Compare differences in host response to co-infections, disease risk and treatment response to elucidate how the ubiquitous co-infections contribute to variations in disease incidence and outcomes.

Voting

9 votes
Ideate

AoU Research Priorities Use Cases

Is there an association between chemical exposures and neurological disease?

Epidemiological studies and anecdotal reports suggest an association between certain neurological diseases (e.g. Parkinson's, Alzheimer's, ALS, various neurodevelopmental disorders) and chemical exposures (pesticides,metals, endocrine disruptors) via residential, occupational, and other activities. The study, using genetic information captured could also possible shed light on Gene-Environment interactions as well.

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31 votes
Ideate