(@jodyetheloner)

AoU Research Priorities Use Cases

Can you find a cure for tmau ( how to fix the FMO3 enzyme in our digestive system)

I have no clue how I would study it to be completely honest... But I have horrible body odor and terrible bad breath because of Trimethylaminuria (tmau). It is caused by a deficiency of flavin monooxygenase 3 (FMO3) secondary to mutations in the FMO3 gene. Please help me and others with this problem.

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10 votes
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(@nichd.allofus)

AoU Research Priorities Use Cases

What are the genetic and environmental risk factors that contribute to the broader autism phenotype in adolescents and adults?

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later... more »

Voting

42 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the genetic and environmental risk factors that contribute to the broader autism phenotype in adolescents and adults?

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later... more »

Voting

42 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

Voting

120 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

Voting

120 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

How do genetic factors of ADHD influence treatment strategies? Can they affect success of treatment or the choice of therapy?

Screen school-age children for ADHD by testing, if feasible, or by electronic health record search. Perform WGS on children as the preferred strategy to identify new genetic associations and confirm previously reported genetic associations. If WGS is not possible, develop a marker panel and test children who have ADHD for known or suspected genetic factors. Follow children by periodic medical evaluations and school performance... more »

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94 votes
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