Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »
Exercise, socialization, cognitive training, education, dietary habits and environmental exposures interacting with genetic profiles are suggested to raise the risk of Alzheimer’s dementia. Less is known about environmental, genetic and epigenetic contributors to raising the risk of dementia with Lewy bodies. Large scale data sets would allow first-of-its-kind enhanced profiling in multi-path analyses key midlife factors... more »
To assess and compare the level of understanding, engagement and satisfaction in patients who received pharmacogenetic results and are randomized to 1) a web-based portal with personalized educational content tailored to subject's results or 2)standard of care. Subjects will be surveyed to determine 1) understanding 2) engagement and 3) satisfaction.
I would design a seven-year-long protocol study that would observe children social developmental stages from various demographics from the pre-school to the fifth-grade. As we look at their food-nutrient intake; family social structure-dynamics environment; social interaction; extracurricular activities; and educational resources in order to see how to reduce disadvantage youth while increase child readiness.
Lung disease, particularly COPD, is the third largest killer among diseases in the United States, and fourth in the world. Nonetheless, the early signs of the diseases are subtle and slow to advance, leading to late diagnosis. Once diagnosed, there is a great reluctance to the lifestyle changes necessary to slow the advancement of the disorder. Smoking addiction, the stigma of smoking history, reluctance to show weakness... more »