(@brodyj)

AoU Research Priorities Use Cases

What are the best ways to report back to participants on biomarkers for environmental chemicals?

All of Us has committed to reporting back to participants on their biomarkers. The study can advance methods for reporting on environmental chemicals in the context of genetic data and health by studying the experiences of All of Us participants, including how they view and use their reports, their cognitive and emotional responses, and other outcomes.

Voting

5 votes
Ideate
(@brodyj)

AoU Research Priorities Use Cases

Does exposure to environmental chemicals, such as PFAS, affect incidence of autoimmune disease in young adults?

By prospectively assessing exposures to environmental chemicals, such as per- and polyfluoroalkyl substances (PFAS), All of Us could evaluate whether these exposures are contributing to the rising incidence of autoimmune diseases in young adults. Intermediate biological outcomes related to thyroid function, inflammation, and immune response could be assessed.

Voting

5 votes
Ideate
(@brodyj)

AoU Research Priorities Use Cases

Does exposure to endocrine disrupting compounds (EDCs) influence the effectiveness of treatments for hormonal cancers?

EDCs are widespread in consumer products, air, and drinking water. Cancer treatments (such as tamoxifen and aromatase inhibitors for breast cancers) depend on altering the body's hormone levels. All of Us could evaluate whether EDCs interfere with cancer treatments. This study would involve assessing EDC exposure in patients during treatment and evaluating hormonal outcomes and disease progression outcomes.

Voting

2 votes
Ideate
(@brodyj)

AoU Research Priorities Use Cases

Does exposure to endocrine disrupting compounds (EDCs) influence the effectiveness of treatments for hormonal cancers?

EDCs are widespread in consumer products, air, and drinking water. Cancer treatments (such as tamoxifen and aromatase inhibitors for breast cancers) depend on altering the body's hormone levels. All of Us could evaluate whether EDCs interfere with cancer treatments. This study would involve assessing EDC exposure in patients during treatment and evaluating hormonal outcomes and disease progression outcomes.

Voting

2 votes
Ideate
(@niehsextramural)

AoU Research Priorities Use Cases

How environmental chemicals mediate/influence comorbid chronic diseases?

Two of the greatest public health challenges facing the US today are obesity and asthma. These two comorbid conditions are also implicated in downstream disorders such as diabetes and CVD. There is evidence that environmental exposures contribute to a rapid increase in disease incidence. Using the AoU cohort to understand how environmental exposures exacerbate the cormbidity between these conditions and subsequent disease ...more »

Voting

15 votes
Ideate
(@jpcastner15)

AoU Research Priorities Use Cases

What are the health effects of sustained ambient exposure above state/fed health-based annual guideline concentrations?

For communities that have sustained (1+ years) ambient and community exposure levels above EPA and/or state environmental agency health-based annual guideline concentrations (e.g. US vs. Tonawanda Coke 10-CR-219-S with increased residential neighborhood levels of PAH's and aldehydes). For these communities seeking research on the increased relative risk of rare disease outcomes, like leukemia, best served by the scale ...more »

Voting

4 votes
Ideate
(@jpcastner15)

AoU Research Priorities Use Cases

What are the multi-level, environmental exposure endotype pathways of autoimmune inflammation and disease? Reactive airway?

Focusing recruitment on communities with a disproportionate burden of environmental exposures, develop and test a multi-level model to ascertain the burden of autoimmune inflammation, autoimmune disease, and reactive airway attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden, and 5) inflammatory biomarker response levels over time. Ascertain how genetic ...more »

Voting

7 votes
Ideate
(@atrenthamd)

AoU Research Priorities Use Cases

Is mammographic breast density causally related to breast cancer and/or an intermediate risk factor for breast cancer?

Breast cancer is the most common cancer in US women. Breast density, usually measured from mammograms, is a strong risk factor for breast cancer and is correlated with many other risk factors, but it is unknown whether changes in breast density reflect changes in breast cancer risk. Importantly, breast density provides a measure of breast cancer risk during menopause when endogenous hormone levels are changing and breast ...more »

Voting

8 votes
Ideate
(@atrenthamd)

AoU Research Priorities Use Cases

Exposures to environmental chemicals during pregnancy and effects on epigenetic biomarkers of metabolic syndrome and obesity

Obesity and breast cancer are leading cause of morbidity and mortality. Evidence strongly suggests that certain periods of life, including those during fetal development and pregnancy, influence risk of breast cancer later in life. Environmental chemicals may increase breast cancer risk-especially during pregnancy-by mimicking estrogen and other hormones. Epigenomic signatures present in the placenta uniquely capture ...more »

Voting

9 votes
Ideate
(@ginawei)

AoU Research Priorities Use Cases

What are the impact of common environmental exposures on cardiovascular (CV) and other health outcomes?

We are constantly exposed to environmental exposures such as air pollution, allergens, and man-made chemicals. AoU offers a unique opportunity to collect such exposures both passively (e.g., linking to local environmental data) and actively (e.g., using novel mHealth devices to measure new data from individual AoU participants). These can be overlaid with behavioral, clinical, genomics, and biological data in AoU to assess ...more »

Voting

19 votes
Ideate
(@ginawei)

AoU Research Priorities Use Cases

What are the impact of common environmental exposures on cardiovascular (CV) and other health outcomes?

We are constantly exposed to environmental exposures such as air pollution, allergens, and man-made chemicals. AoU offers a unique opportunity to collect such exposures both passively (e.g., linking to local environmental data) and actively (e.g., using novel mHealth devices to measure new data from individual AoU participants). These can be overlaid with behavioral, clinical, genomics, and biological data in AoU to assess ...more »

Voting

19 votes
Ideate
(@jaime.hart)

AoU Research Priorities Use Cases

How do exposures to multiple environmental stressors impact chronic disease risk

The goal would be to examine the associations between multiple environmental stressors (air pollutants, temperature, etc) on chronic disease risk, and how these associations are modified by inherent characteristics, lifestyle factors, and the built and natural environments. This would require current & historical residential/work addresses and appending environmental data. This would provide more information on how these ...more »

Voting

27 votes
Ideate
(@alan.sanders.md)

AoU Research Priorities Use Cases

Which genetic and environmental factors contribute to sexual orientation, and related health conditions?

Gays, lesbians, and bisexuals are underrepresented in biomedical research. While much relevant data is already planned for collection by AllofUs, additional or elaborated measures (see "data items") would help in seeking new leads and advancing work on pre-existing questions in the field. These items include sociodemographic (e.g., trait information), clinical (various associated conditions), and biological (genomic, ...more »

Voting

30 votes
Ideate