(@abaccarelli)

AoU Research Priorities Use Cases

Does the human epigenome reflect exposure to environmental chemicals?

The human epigenome is altered by environmental pollutants, including particulate air pollution, bisphenol A, phthalates, metals, pesticides, dioxin-like compounds, and persistent organic pollutants. All of us will be uniquely positioned to link exposure to environmental chemicals with alterations in the human epigenome. This will require refined measures of environmental exposure that—if measured in All of us—will cause... more »

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(@abaccarelli)

AoU Research Priorities Use Cases

Does the human epigenome reflect exposure to environmental chemicals?

The human epigenome is altered by environmental pollutants, including particulate air pollution, bisphenol A, phthalates, metals, pesticides, dioxin-like compounds, and persistent organic pollutants. All of us will be uniquely positioned to link exposure to environmental chemicals with alterations in the human epigenome. This will require refined measures of environmental exposure that—if measured in All of us—will cause... more »

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4 votes
Ideate
(@niehs.cem)

AoU Research Priorities Use Cases

What are the combined environmental exposures that contribute to disease?

Measure as many environmental chemical and nonchemical exposures as feasible using internal and external exposure monitoring technologies. Utilize different statistical approaches for evaluating the association of multiple exposures to biomarkers of disease. Statistical methods can also be used to identify common exposure combinations, which can be prioritized for further study in animal and in vitro models.

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11 votes
Ideate