Showing 5 ideas for tag "environmental-exposures"
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Does the human epigenome reflect exposure to environmental chemicals?

The human epigenome is altered by environmental pollutants, including particulate air pollution, bisphenol A, phthalates, metals, pesticides, dioxin-like compounds, and persistent organic pollutants. All of us will be uniquely positioned to link exposure to environmental chemicals with alterations in the human epigenome. This will require refined measures of environmental exposure that—if measured in All of us—will cause... more »

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The AoU Exposome Study: Untargeted Discovery of environment-disease associations

The exposome has been defined as the totality of environmental exposures throughout the life-course. Regardless of the definition it is as a tool for the untargeted hypothesis free discovery of associations between environmental exposures and disease outcomes. This is best applied to high prevalence phenotypes that are likely to occur in the cohort such as the conversion of metabolic syndrome to overt diabetes where it... more »

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What is the functional mechanism when environmental exposures are associated with human health effects? Vary by age of exposure?

Using biospecimens of persons of varying ages, characterize exposure to environmental chemicals and metals over time and conduct omics studies to identify the functional mechanism of observed health effects - gene expression, metabolomics, epigenetics and genetic variants. Most important, have a plan for integrating the findings of these various studies.

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