AoU Research Priorities Use Cases

AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and ...more »

Voting

1 vote
Ideate
(@jpcastner15)

AoU Research Priorities Use Cases

What are the health effects of sustained ambient exposure above state/fed health-based annual guideline concentrations?

For communities that have sustained (1+ years) ambient and community exposure levels above EPA and/or state environmental agency health-based annual guideline concentrations (e.g. US vs. Tonawanda Coke 10-CR-219-S with increased residential neighborhood levels of PAH's and aldehydes). For these communities seeking research on the increased relative risk of rare disease outcomes, like leukemia, best served by the scale ...more »

Voting

4 votes
Ideate
(@jpcastner15)

AoU Research Priorities Use Cases

What are the health effects of sustained ambient exposure above state/fed health-based annual guideline concentrations?

For communities that have sustained (1+ years) ambient and community exposure levels above EPA and/or state environmental agency health-based annual guideline concentrations (e.g. US vs. Tonawanda Coke 10-CR-219-S with increased residential neighborhood levels of PAH's and aldehydes). For these communities seeking research on the increased relative risk of rare disease outcomes, like leukemia, best served by the scale ...more »

Voting

4 votes
Ideate
(@jpcastner15)

AoU Research Priorities Use Cases

What are the multi-level, environmental exposure endotype pathways of autoimmune inflammation and disease? Reactive airway?

Focusing recruitment on communities with a disproportionate burden of environmental exposures, develop and test a multi-level model to ascertain the burden of autoimmune inflammation, autoimmune disease, and reactive airway attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden, and 5) inflammatory biomarker response levels over time. Ascertain how genetic ...more »

Voting

7 votes
Ideate
(@jpcastner15)

AoU Research Priorities Use Cases

What are the multi-level, immune-mediated, environmental exposure endotype pathways of environmental illness? Asthma/allergies?

Focusing recruitment on communities with a disproportionate burden of environmental exposure (such as Western New York), develop and test a multi-level model to ascertain the burden of environmental illness symptom clusters, asthma, and allergies attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden 5) inflammatory biomarker response levels over time. ...more »

Voting

5 votes
Ideate
(@jpcastner15)

AoU Research Priorities Use Cases

What are the multi-level, immune-mediated, environmental exposure endotype pathways of environmental illness? Asthma/allergies?

Focusing recruitment on communities with a disproportionate burden of environmental exposure (such as Western New York), develop and test a multi-level model to ascertain the burden of environmental illness symptom clusters, asthma, and allergies attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden 5) inflammatory biomarker response levels over time. ...more »

Voting

5 votes
Ideate
(@blp2125)

AoU Research Priorities Use Cases

How can novel and expansive exposure monitoring with wearable technology improve environmental-disease outcome discovery?

Currently, environmental exposure monitoring measure classic or persistent chemical exposures, but might fail to analyze newer chemicals. Many newer chemicals are high production volume, but are nevertheless not assessed in population or in study-targeted analyses, but may, in fact, be associated with risk to human or animal health. New personal wearable silicone band monitoring devices, such as those designed Dr. Kim ...more »

Voting

6 votes
Ideate
(@blp2125)

AoU Research Priorities Use Cases

How can novel and expansive exposure monitoring with wearable technology improve environmental-disease outcome discovery?

Currently, environmental exposure monitoring measure classic or persistent chemical exposures, but might fail to analyze newer chemicals. Many newer chemicals are high production volume, but are nevertheless not assessed in population or in study-targeted analyses, but may, in fact, be associated with risk to human or animal health. New personal wearable silicone band monitoring devices, such as those designed Dr. Kim ...more »

Voting

6 votes
Ideate
(@noemie.elhadad)

AoU Research Priorities Use Cases

What are the genetic, epigenetic, and environmental factors of endometriosis, and how can they help us identify its subtypes?

Endometriosis is a systemic condition with a heavy burden on patients. It is estimated that 10% of women in reproductive age have endometriosis, but its etiology is still unknown. While it is accepted that endometriosis is a heterogeneous condition, what the exact subtypes of the disease are is still an open question.

Voting

144 votes
Ideate
(@noemie.elhadad)

AoU Research Priorities Use Cases

What are the genetic, epigenetic, and environmental factors of endometriosis, and how can they help us identify its subtypes?

Endometriosis is a systemic condition with a heavy burden on patients. It is estimated that 10% of women in reproductive age have endometriosis, but its etiology is still unknown. While it is accepted that endometriosis is a heterogeneous condition, what the exact subtypes of the disease are is still an open question.

Voting

144 votes
Ideate
(@bcarverme)

AoU Research Priorities Use Cases

Investigate the role of environmental and dietary factors in the incidence of chronic pain

Investigate the correlation between the incidence of reported pain and various social and biological characteristics. Investigate the correlation between the incidence of reported pain and dietary factors including foods, food additives such as dyes, preservatives and other additives. Investigate the correlation between the incidence of reported pain and environmental exposures including pollution, pesticides and the ...more »

Voting

23 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What factors are involved in loss of fecundity in males and females?

This study will focus on the entire cohort across the reproductive lifespan (ages 12-55) collecting data on fertility (time to conception) and pregnancy loss. Additional data will include factors believed to be indicators of fertility as determined by questionnaire, blood tests, factors believed to negatively impact fertility, and genetic/epigenetic data that together may provide new targets for understanding oocyte depletion, ...more »

Voting

29 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What factors are involved in loss of fecundity in males and females?

This study will focus on the entire cohort across the reproductive lifespan (ages 12-55) collecting data on fertility (time to conception) and pregnancy loss. Additional data will include factors believed to be indicators of fertility as determined by questionnaire, blood tests, factors believed to negatively impact fertility, and genetic/epigenetic data that together may provide new targets for understanding oocyte depletion, ...more »

Voting

29 votes
Ideate