AoU Research Priorities Use Cases

AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »

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1 vote
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(@rotunnom)

AoU Research Priorities Use Cases

Identifying and understanding the genetic and epigenetic factors associated with disease

Combining genome-wide genetic/epigenetic variation and gene/protein expression with clinical, behavioral, imaging, environmental, and molecular data, in the large and diverse All of Us cohort will enhance our understanding of disease risk factors and subtypes, relevant biological processes, and targeted treatments. Methods involved include: genomic data generation, storage and sharing; data integration, visualization,... more »

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2 votes
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(@lisa.signorello)

AoU Research Priorities Use Cases

Is the seminal fluid microbiome associated with incident prostate cancer risk?

Prostate cancer has long been suspected to include an infectious etiology, although no agent has been identified. It is possible that one specific virus or bacterium is not significant, but rather the characteristics of the entire microbiota to which the prostate is exposed (e.g., the abundance and diversity of all microorganisms). This may be capturable by examining the seminal fluid microbiome.

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1 vote
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(@lisa.signorello)

AoU Research Priorities Use Cases

To develop or optimize a non-invasive BIOMARKER that can be used to measure the experience of stress in children and adults.

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

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3 votes
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(@lisa.signorello)

AoU Research Priorities Use Cases

To develop or optimize a non-invasive TECHNOLOGY that can be used to measure the experience of stress in children and adults.

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine wearable technologies that could help push this field of research forward in a valid way for the future. Such technology could be a part of individual studies of stress and disease, and could also be used as a gold standard... more »

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3 votes
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AoU Research Priorities Use Cases

Can the recycling of influenza viruses explain changes in phenotypes of CHD cases?

I proposed that the 1950s-60s CHD deaths were associated with H1-H2 Influenza A re-infectiosn of H3 Influenza primed individuals (born around 1890). After 1968, when the H3 influenza virus returned, high serum cholesterol CHD cases declined and a second atherogenic phenotype emerged (H3 re-infection of H1-primed cohorts born after 1900 and more after 1918?). Would CHD mortality with high serum cholesterol levels increase... more »

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1 vote
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(@junseok.chae)

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Determine Who is at Risk for Preventable Infectious Diseases?

We will obtain a one-time blood measurement of immunity to preventable infectious diseases, such as measles, mumps, and human papillomavirus in people who have been vaccinated. This will help identify people who do not respond strongly to certain vaccines, to identify at-risk populations for infectious diseases and HPV-associated cancers. The goal is to develop targeted vaccination and prevention strategies for infectious... more »

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3 votes
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(@alex.breskin)

AoU Research Priorities Use Cases

How has the opioid abuse epidemic impacted hepatitis C incidence?

Hepatitis C virus (HCV) is often transmitted through the use of shared injection drug paraphernalia. With the rise in opioid abuse, it is reasonable to expect a corresponding rise in HCV incidence. Current treatments can effectively cure HCV, making it more important than ever to identify those most at risk. Using data from this cohort, we can determine the current incidence of HCV and its association with opioid use,... more »

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3 votes
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(@margit)

AoU Research Priorities Use Cases

Interaction between diet, sleep, alcohol use, stress genetics and depression risk

Cardiovascular disease and depression are associated, but direction is unclear - or both (heart attack is a stressor triggering depression, depression leads to less exercise and increases CVD). Sleep disturbance is associated with alcohol and depression - cause and effect unclear. Alcohol can increase depression risk, and vice versa. Increasing omega-3 vs. omega-6 may be preventive for both depression and CVD. AOU is... more »

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41 votes
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(@margit)

AoU Research Priorities Use Cases

Interaction between diet, sleep, alcohol use, stress genetics and depression risk

Cardiovascular disease and depression are associated, but direction is unclear - or both (heart attack is a stressor triggering depression, depression leads to less exercise and increases CVD). Sleep disturbance is associated with alcohol and depression - cause and effect unclear. Alcohol can increase depression risk, and vice versa. Increasing omega-3 vs. omega-6 may be preventive for both depression and CVD. AOU is... more »

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41 votes
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(@arianasmith)

AoU Research Priorities Use Cases

Do self-reported Nocturia episodes correlate with actual nighttime visits to the toilet; what is the natural history of nocturia

Nocturia is highly prevalent and has significant impact on quality of life. Therapeutic interventions often reduce nocturia episodes by less than one episode per night and rely on self-report data to quantify efficacy. This study will identify a cohort with nocturia and compare self-reported nocturia to actual nighttime visits to the toilet as recorded by wearable technology; and follow over time. We hypothesize that... more »

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21 votes
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