(@judithjames808)

AoU Research Priorities Use Cases

What environmental and genetic factors influence the development of osteoarthritis?

Osteoarthritis (OA) is the most common cause of disability in the United States, and there are no available biomarkers or disease-modifying therapies for OA. Currently, we are unable to identify rapidly progressive OA patients at diagnosis. All of Us offers a unique opportunity to obtain clinical data and biospecimens, along with diet and exercise information, which associate with rapidly progressive OA to help foster... more »

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2 votes
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(@judithjames808)

AoU Research Priorities Use Cases

What environmental and genetic factors influence the development of osteoarthritis?

Osteoarthritis (OA) is the most common cause of disability in the United States, and there are no available biomarkers or disease-modifying therapies for OA. Currently, we are unable to identify rapidly progressive OA patients at diagnosis. All of Us offers a unique opportunity to obtain clinical data and biospecimens, along with diet and exercise information, which associate with rapidly progressive OA to help foster... more »

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2 votes
Ideate
(@abaccarelli)

AoU Research Priorities Use Cases

Does the human epigenome reflect exposure to environmental chemicals?

The human epigenome is altered by environmental pollutants, including particulate air pollution, bisphenol A, phthalates, metals, pesticides, dioxin-like compounds, and persistent organic pollutants. All of us will be uniquely positioned to link exposure to environmental chemicals with alterations in the human epigenome. This will require refined measures of environmental exposure that—if measured in All of us—will cause... more »

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4 votes
Ideate
(@abaccarelli)

AoU Research Priorities Use Cases

Does the human epigenome reflect exposure to environmental chemicals?

The human epigenome is altered by environmental pollutants, including particulate air pollution, bisphenol A, phthalates, metals, pesticides, dioxin-like compounds, and persistent organic pollutants. All of us will be uniquely positioned to link exposure to environmental chemicals with alterations in the human epigenome. This will require refined measures of environmental exposure that—if measured in All of us—will cause... more »

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4 votes
Ideate

AoU Research Priorities Use Cases

AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »

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1 vote
Ideate
(@lisa.signorello)

AoU Research Priorities Use Cases

To what extent are adverse childhood experiences (ACE) or trauma related to a wide range of adult diseases or premature death?

Adverse childhood experiences (ACE) can be retrospectively assessed in adults, ideally before the onset of the diseases under study. There are existing ACE instruments, or attempts to refine these instruments could be undertaken within All of Us.

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5 votes
Ideate
(@lisa.signorello)

AoU Research Priorities Use Cases

To develop or optimize a non-invasive BIOMARKER that can be used to measure the experience of stress in children and adults.

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

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3 votes
Ideate
(@lisa.signorello)

AoU Research Priorities Use Cases

To develop or optimize a non-invasive TECHNOLOGY that can be used to measure the experience of stress in children and adults.

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine wearable technologies that could help push this field of research forward in a valid way for the future. Such technology could be a part of individual studies of stress and disease, and could also be used as a gold standard... more »

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3 votes
Ideate

AoU Research Priorities Use Cases

Do genomic, epigenetic, and metabolomic characteristics explain the excess risk of type 2 diabetes (T2D) in Asian-Americans?

California data shows T2D prevalence is higher among Pacific Islanders, Filipinos and South Asians, compared to Latinos, African-Americans, and Native Americans; further, Chinese, Japanese, and Koreans in California have a 50% higher risk of T2D compared to Whites. High throughput technologies, including metabolomics and genomics could provide valuable insight regarding the etiology of T2D disease mechanisms, and novel... more »

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9 votes
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(@svogelstein)

AoU Research Priorities Use Cases

What etiology factors contribute to the onset of seizures in late adulthood?

The incidence of seizures increases after the age of 50 years. With the increased life expectancy, seizures in older adults represents an emerging and important public health concern. Although cerebrovascular disease contributes to some cases, the etiology of these seizures in most patients is large known. Metabolic factors are likely to contribute to risk in some patients as diet changes can reduce the frequency of seizures... more »

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3 votes
Ideate
(@svogelstein)

AoU Research Priorities Use Cases

What etiology factors contribute to the onset of seizures in late adulthood?

The incidence of seizures increases after the age of 50 years. With the increased life expectancy, seizures in older adults represents an emerging and important public health concern. Although cerebrovascular disease contributes to some cases, the etiology of these seizures in most patients is large known. Metabolic factors are likely to contribute to risk in some patients as diet changes can reduce the frequency of seizures... more »

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3 votes
Ideate
(@renaissance)

AoU Research Priorities Use Cases

How reliably do epigenetic aging clocks predict disease onset and mortality? Can they be slowed or reversed?

An annual blood test with analysis of methylation sites from key epigenetic aging clocks (e.g. Horvath). Epigenetic aging clocks have already been shown to reliably predict age, time-to-death, all cause mortality, cog. function, immune function, CV disease, cancer, and more. They may also become a key tool to demonstrate the reversibility of disease risk through dietary and therapeutic regimens, as epigenetic states are... more »

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35 votes
Ideate

AoU Research Priorities Use Cases

Genetic, epigenetic, and microbiome contributions to hypertension

The goal would be to enhance our understanding of how social and environmental exposures, genomic factors, and gut microbiota interact to influence hypertension susceptibility and phenotype. This would require integrated analyses of genomic and other -omics data, exposures, and phenotype data, and could lead to insights that enable more targeted prevention and treatment. Inherent in this would be discovery of pathways... more »

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6 votes
Ideate

AoU Research Priorities Use Cases

Genetic, epigenetic, and microbiome contributions to hypertension

The goal would be to enhance our understanding of how social and environmental exposures, genomic factors, and gut microbiota interact to influence hypertension susceptibility and phenotype. This would require integrated analyses of genomic and other -omics data, exposures, and phenotype data, and could lead to insights that enable more targeted prevention and treatment. Inherent in this would be discovery of pathways... more »

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6 votes
Ideate
(@atrenthamd)

AoU Research Priorities Use Cases

Exposures to environmental chemicals during pregnancy and effects on epigenetic biomarkers of metabolic syndrome and obesity

Obesity and breast cancer are leading cause of morbidity and mortality. Evidence strongly suggests that certain periods of life, including those during fetal development and pregnancy, influence risk of breast cancer later in life. Environmental chemicals may increase breast cancer risk-especially during pregnancy-by mimicking estrogen and other hormones. Epigenomic signatures present in the placenta uniquely capture... more »

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9 votes
Ideate