Aim 2. Comparative Effectiveness. For each epilepsy subtype, which medication works best?
Aim 3. Pharmacogenetics. Within epilepsy subtypes, what genetic markers predict response to treatment?
(Epilepsy subtypes might include new onset focal epilepsy, new onset generalized epilepsy, Dravet syndrome, Doose... more »
Gather MRI, genetic and basic clinical and behavioral data from all patients with epilepsy (conservatively 1% of the population). Data can then be analyzed using a machine learning approach to identify consistencies and differences among patients which can then inform our understanding of epilepsy subtypes and subsequent treatment decisions.
Justification: as the US population ages, the incidence and prevalence of epilepsy is expected to increase, given the association of epilepsy... more »