Showing 5 ideas for tag "epilepsy"
(@svogelstein) kudos icon +

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What etiology factors contribute to the onset of seizures in late adulthood?

The incidence of seizures increases after the age of 50 years. With the increased life expectancy, seizures in older adults represents an emerging and important public health concern. Although cerebrovascular disease contributes to some cases, the etiology of these seizures in most patients is large known. Metabolic factors are likely to contribute to risk in some patients as diet changes can reduce the frequency of seizures... more »

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3 votes
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(@mveenker) kudos icon +

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What are the connections exist between comorbid brain disorders such as epilepsy and bipolar disorder and MS?

Too many people have comorbid brain disorders. Not enough is known each disease independently, what causes them and what, if anything, contributes to resilience in the rest of us who do not suffer from them. Research on familial links, people with similar comorbid brain disorders, genetics that play into who gets these diseases and how individuals react uniquely to medications can all lead us to a better understanding,... more »

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4 votes
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(@grizac) kudos icon +

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What medications work best for people with epilepsy?

Aim 1. Pharmacoepidemiology. Among people with epilepsy subtypes, what are the most commonly used medications?

Aim 2. Comparative Effectiveness. For each epilepsy subtype, which medication works best?

Aim 3. Pharmacogenetics. Within epilepsy subtypes, what genetic markers predict response to treatment?

(Epilepsy subtypes might include new onset focal epilepsy, new onset generalized epilepsy, Dravet syndrome, Doose... more »

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12 votes
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(@skbandt) kudos icon +

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Can we advance our understanding of epilepsy by developing new, data-driven tools for use in its diagnosis and treatment?

Gather MRI, genetic and basic clinical and behavioral data from all patients with epilepsy (conservatively 1% of the population). Data can then be analyzed using a machine learning approach to identify consistencies and differences among patients which can then inform our understanding of epilepsy subtypes and subsequent treatment decisions.

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11 votes
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(@adam.hartman) kudos icon +

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What are the risk factors (genetic, environmental, other biological) for developing epilepsy later in life?

Initial data (e.g., demographic) and data that are noted routinely as a part of healthcare maintenance (e.g., anthropomorphic factors, blood pressure, cholesterol, serum creatinine, etc.) could be collected longitudinally and then evaluated in terms of onset of epilepsy later in life.
Justification: as the US population ages, the incidence and prevalence of epilepsy is expected to increase, given the association of epilepsy... more »

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12 votes
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