(@eofili)

AoU Research Priorities Use Cases

Can mobile health technology monitor/ track spirometry and detect acute decompensation in childhood asthma?

Acute exacerbation accounts for frequent and recurrent ER visits in children with asthma. Genetic susceptibility and interaction with factors such as infection/inflammation, exposure to environmental pollutants may contribute to acute decompensation. Predictive modeling using multiple data points including genetic variants, environmental exposure, and self monitored spirometry may help with early detection and intervention ...more »

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0 votes
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(@mechanil)

AoU Research Priorities Use Cases

How do genomic, biological, environmental and societal factors combine to contribute to disease risk?

Complex diseases are a result of a complex interplay of genetic, environmental, host and societal factors operating over a prolonged time. Many factors associated with disease onset or progression have been elucidated using a silo-ed approach which fails to adequately assess interplay between factors. Longitudinal measures and more sophisticated analytical methods are needed to support comprehensive (e.g. systems or computational ...more »

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2 votes
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AoU Research Priorities Use Cases

AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and ...more »

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1 vote
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(@jpcastner15)

AoU Research Priorities Use Cases

What are the multi-level, environmental exposure endotype pathways of autoimmune inflammation and disease? Reactive airway?

Focusing recruitment on communities with a disproportionate burden of environmental exposures, develop and test a multi-level model to ascertain the burden of autoimmune inflammation, autoimmune disease, and reactive airway attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden, and 5) inflammatory biomarker response levels over time. Ascertain how genetic ...more »

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7 votes
Ideate
(@jpcastner15)

AoU Research Priorities Use Cases

What are the multi-level, immune-mediated, environmental exposure endotype pathways of environmental illness? Asthma/allergies?

Focusing recruitment on communities with a disproportionate burden of environmental exposure (such as Western New York), develop and test a multi-level model to ascertain the burden of environmental illness symptom clusters, asthma, and allergies attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden 5) inflammatory biomarker response levels over time. ...more »

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5 votes
Ideate
(@jpcastner15)

AoU Research Priorities Use Cases

What are the multi-level, immune-mediated, environmental exposure endotype pathways of environmental illness? Asthma/allergies?

Focusing recruitment on communities with a disproportionate burden of environmental exposure (such as Western New York), develop and test a multi-level model to ascertain the burden of environmental illness symptom clusters, asthma, and allergies attributable to environmental factors at the 1) community/neighborhood, 2) household, 3) personal, 4) internal body burden 5) inflammatory biomarker response levels over time. ...more »

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5 votes
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(@margit)

AoU Research Priorities Use Cases

Interaction between diet, sleep, alcohol use, stress genetics and depression risk

Cardiovascular disease and depression are associated, but direction is unclear - or both (heart attack is a stressor triggering depression, depression leads to less exercise and increases CVD). Sleep disturbance is associated with alcohol and depression - cause and effect unclear. Alcohol can increase depression risk, and vice versa. Increasing omega-3 vs. omega-6 may be preventive for both depression and CVD. AOU is ...more »

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41 votes
Ideate
(@margit)

AoU Research Priorities Use Cases

Interaction between diet, sleep, alcohol use, stress genetics and depression risk

Cardiovascular disease and depression are associated, but direction is unclear - or both (heart attack is a stressor triggering depression, depression leads to less exercise and increases CVD). Sleep disturbance is associated with alcohol and depression - cause and effect unclear. Alcohol can increase depression risk, and vice versa. Increasing omega-3 vs. omega-6 may be preventive for both depression and CVD. AOU is ...more »

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41 votes
Ideate