(@andrea.h.ramirez)

AoU Research Priorities Use Cases

Estimate risk for common disease such as diabetes from genetic factors, dietary habits, and geolocalization data

Estimate risk for common disease or health outcomes based on known genetic factors combined with novel environmental data types such as proximity to food sources and pollution and laboratory measures of pollutant exposure, for example, what is the relative risk of genetic factors for diabetes compared to dietary habits and proximity to grocery stores?

Voting

0 votes
Ideate
(@changhu)

AoU Research Priorities Use Cases

What are the long-term cardiovascular effects of cancer therapy? Do childhood cancer survivors have reduced cardiac functions?

To study adult cancer survivors who received cancer therapy during childhood. What are their cardiovascular functions as compared to adults who did not receive cancer therapy. Reduction of cardiovascular functions after anticancer therapy may take years to develop. These undesirable complications can compromise quality of life or shorten life span. This study will provide evidence-based guidelines for physicians to choose... more »

Voting

17 votes
Ideate
(@changhu)

AoU Research Priorities Use Cases

What are the long-term cardiovascular effects of cancer therapy? Do childhood cancer survivors have reduced cardiac functions?

To study adult cancer survivors who received cancer therapy during childhood. What are their cardiovascular functions as compared to adults who did not receive cancer therapy. Reduction of cardiovascular functions after anticancer therapy may take years to develop. These undesirable complications can compromise quality of life or shorten life span. This study will provide evidence-based guidelines for physicians to choose... more »

Voting

17 votes
Ideate
(@changhu)

AoU Research Priorities Use Cases

What are the genetic, comorbid risk factors, and anticancer agents that contribute to heart failure after cancer therapy

Goals:To study the epidemiology of cardiovascular complications of cancer therapy in order to design prevention strategy and precision treatment of cancer patients while minimizing debilitating cardiovascular complications. Methods: compare data on genetic, co morbid risk factors, and anticancer agents used in association with cardiovascular complications after cancer therapy. Expected outcomes: This study will provide... more »

Voting

11 votes
Ideate
(@changhu)

AoU Research Priorities Use Cases

What are the genetic, comorbid risk factors, and anticancer agents that contribute to heart failure after cancer therapy

Goals:To study the epidemiology of cardiovascular complications of cancer therapy in order to design prevention strategy and precision treatment of cancer patients while minimizing debilitating cardiovascular complications. Methods: compare data on genetic, co morbid risk factors, and anticancer agents used in association with cardiovascular complications after cancer therapy. Expected outcomes: This study will provide... more »

Voting

11 votes
Ideate
(@noemie.elhadad)

AoU Research Priorities Use Cases

What are the genetic, epigenetic, and environmental factors of endometriosis, and how can they help us identify its subtypes?

Endometriosis is a systemic condition with a heavy burden on patients. It is estimated that 10% of women in reproductive age have endometriosis, but its etiology is still unknown. While it is accepted that endometriosis is a heterogeneous condition, what the exact subtypes of the disease are is still an open question.

Voting

144 votes
Ideate
(@noemie.elhadad)

AoU Research Priorities Use Cases

What are the genetic, epigenetic, and environmental factors of endometriosis, and how can they help us identify its subtypes?

Endometriosis is a systemic condition with a heavy burden on patients. It is estimated that 10% of women in reproductive age have endometriosis, but its etiology is still unknown. While it is accepted that endometriosis is a heterogeneous condition, what the exact subtypes of the disease are is still an open question.

Voting

144 votes
Ideate

AoU Research Priorities Use Cases

Which genetic variants are associated with intentional weight loss in response to a lifestyle weight loss intervention?

The prevalence of overweight and obesity is a worldwide epidemic. Genomic and genetic studies have advanced our knowledge through the identification of genes and susceptibility alleles that increase risk for obesity. However, it is unclear whether these variants also contribute to weight loss as the genetic determinants of weight loss may differ. The identification of genetic predictors of intentional weight loss can... more »

Voting

31 votes
Ideate
(@klosecall)

AoU Research Priorities Use Cases

Can pollen allergies be isolated by genetics, confirmed by allergy testing, and exposure be tracked to limit asthma attacks?

A cohort of asthma patients (who believe they have a pollen allergy) would undergo genetic testing to identify genetic markers. Those patients would undergo blood and skin allergy testing to confirm the allergy, and then the patients would be utilize a mobile monitor to track the weather and environmental exposures (esp. pollen) that are causal to asthma incidences. With a more complete picture of pollen allergen impacts... more »

Voting

39 votes
Ideate
(@eric.sid)

AoU Research Priorities Use Cases

What genetic markers can lead to early diagnosis of late-onset rare diseases (Huntington, Crohn, CMT, ALS, etc.)?

Most rare diseases, defined as those affecting fewer than 200,000 people, are genetic disorders with signs observable at birth or in childhood. However, a number have adult-onsets, such as Crohn, Charcot-Marie-Tooth, ALS or thyroid cancer. Of this subset, many have not been linked to a single genetic mutation or origin and similarly, do not have a usable biomarker for early diagnosis. Are there any genetic markers that... more »

Voting

22 votes
Ideate
(@alison.cernich)

AoU Research Priorities Use Cases

What are the characteristics of people who sustain traumatic injury who have optimal recovery versus those who do not?

Injury to the musculoskeletal system, the central and peripheral nervous system, or other conditions that cause disability are associated with significant morbidity. These injuries have substantial economic cost due to inability to work, high health care costs, and the need for long-term rehabilitation. Bioarkers of plasticity and contextual factors may predict functional outcome and guide prescription of the intensity... more »

Voting

20 votes
Ideate