(@judithjames808)

AoU Research Priorities Use Cases

What environmental and genetic factors influence the development of osteoarthritis?

Osteoarthritis (OA) is the most common cause of disability in the United States, and there are no available biomarkers or disease-modifying therapies for OA. Currently, we are unable to identify rapidly progressive OA patients at diagnosis. All of Us offers a unique opportunity to obtain clinical data and biospecimens, along with diet and exercise information, which associate with rapidly progressive OA to help foster... more »

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2 votes
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(@judithjames808)

AoU Research Priorities Use Cases

What environmental and genetic factors influence the development of osteoarthritis?

Osteoarthritis (OA) is the most common cause of disability in the United States, and there are no available biomarkers or disease-modifying therapies for OA. Currently, we are unable to identify rapidly progressive OA patients at diagnosis. All of Us offers a unique opportunity to obtain clinical data and biospecimens, along with diet and exercise information, which associate with rapidly progressive OA to help foster... more »

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2 votes
Ideate
(@mechanil)

AoU Research Priorities Use Cases

How do genomic, biological, environmental and societal factors combine to contribute to disease risk?

Complex diseases are a result of a complex interplay of genetic, environmental, host and societal factors operating over a prolonged time. Many factors associated with disease onset or progression have been elucidated using a silo-ed approach which fails to adequately assess interplay between factors. Longitudinal measures and more sophisticated analytical methods are needed to support comprehensive (e.g. systems or computational... more »

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2 votes
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(@hcarskaddan)

AoU Research Priorities Use Cases

What genetic, physiological and environmental factors contribute to structural birth defects and functional defects?

Enroll sufficient numbers of pregnant women and offspring to study the genetic and non-genetic factors that contribute to human structural and functional defects and developmental disorders. Recruitment of sufficient pregnancies and pediatric cohorts is important to investigate the cause of birth defects and their long-term effects. A family-based approach will be effective in dissecting the genetic or nongenetic components... more »

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2 votes
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(@huiqingli)

AoU Research Priorities Use Cases

How Genetic and Life Style Factors Contribute to Cardiovascular Diseases in Adults with Congenital Heart Disease

An estimated 1.6 million American adults live with Congenital Heart Disease (CHD), with this group growing at the rate of 40,000 to 50,000 people yearly. This sensitized population have a much higher risk to get cardiovascular diseases. Collecting DNA samples and heart health data to detect how those factors contribute to their heart health. Identification of the risk factors will not only improve life quality and life... more »

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2 votes
Ideate
(@kk4730)

AoU Research Priorities Use Cases

Clinical, environmental, and genetic factors in glomerular disease susceptibility and progression

Glomerular disorders represent the third-most common cause of end-stage kidney disease after diabetes and hypertension. Well-designed and adequately powered clinical, genetic and environmental exposure studies are missing for most glomerular disease types. Using genetic and environmental variables combined with kidney-related structured electronic health record phenotype data captured by All-of-US, we aim to identify... more »

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4 votes
Ideate
(@svogelstein)

AoU Research Priorities Use Cases

What etiology factors contribute to the onset of seizures in late adulthood?

The incidence of seizures increases after the age of 50 years. With the increased life expectancy, seizures in older adults represents an emerging and important public health concern. Although cerebrovascular disease contributes to some cases, the etiology of these seizures in most patients is large known. Metabolic factors are likely to contribute to risk in some patients as diet changes can reduce the frequency of seizures... more »

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3 votes
Ideate
(@svogelstein)

AoU Research Priorities Use Cases

What etiology factors contribute to the onset of seizures in late adulthood?

The incidence of seizures increases after the age of 50 years. With the increased life expectancy, seizures in older adults represents an emerging and important public health concern. Although cerebrovascular disease contributes to some cases, the etiology of these seizures in most patients is large known. Metabolic factors are likely to contribute to risk in some patients as diet changes can reduce the frequency of seizures... more »

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3 votes
Ideate
(@knacct)

AoU Research Priorities Use Cases

What Genetic, General and Oral Health, and Behavioral Factors Contribute to Edentulism?

Edentulism is the end-product of years of poor oral health, with substantial personal, societal, and economic burden. Tracking the multiple factors contributing to this poor oral health outcome will be possible in the AoU database, and could lead to a much more detailed understanding of the genetic and behavioral risk factors involved, including chronic systemic health problems. This is turn may point to specific interventions... more »

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13 votes
Ideate
(@pnatarajan)

AoU Research Priorities Use Cases

How do environmental exposures, behavior, & genetics, in combination, influence risk of atherosclerotic cardiovascular disease.

Genetics can be the earlier risk predictor of common, heritable traits such as atherosclerotic cardiovascular disease (ASCVD). Longitudinal environmental exposures and behavioral practices subsequently modify risk. Uniform dense ascertainment of environmental exposures and behavior is feasible through wearable sensors. We and others are beginning to look at the comprehensive set of exposures that influence ASCVD risk.... more »

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12 votes
Ideate
(@pnatarajan)

AoU Research Priorities Use Cases

How do environmental exposures, behavior, & genetics, in combination, influence risk of atherosclerotic cardiovascular disease.

Genetics can be the earlier risk predictor of common, heritable traits such as atherosclerotic cardiovascular disease (ASCVD). Longitudinal environmental exposures and behavioral practices subsequently modify risk. Uniform dense ascertainment of environmental exposures and behavior is feasible through wearable sensors. We and others are beginning to look at the comprehensive set of exposures that influence ASCVD risk.... more »

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12 votes
Ideate
(@dgormanj)

AoU Research Priorities Use Cases

What is the prevalence of hereditary hemochromatosis in the U.S. population?

Looking for the hereditary hemochromatosis gene (carriers or people who have this recessive disease) in DNA sequencing and blood tests. Testing ferritin, transferritin saturation, TIBC, and iron levels in patient blood labs; testing liver function in patient blood labs; testing chemical panel with glucose in patient blood labs; testing CBC in patient blood labs; testing lipid panel (cholesterol, triglycerides, HDL,... more »

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3 votes
Ideate
(@dgormanj)

AoU Research Priorities Use Cases

What is the prevalence of hereditary hemochromatosis in the U.S. population?

Looking for the hereditary hemochromatosis gene (carriers or people who have this recessive disease) in DNA sequencing and blood tests. Testing ferritin, transferritin saturation, TIBC, and iron levels in patient blood labs; testing liver function in patient blood labs; testing chemical panel with glucose in patient blood labs; testing CBC in patient blood labs; testing lipid panel (cholesterol, triglycerides, HDL,... more »

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3 votes
Ideate
(@megan.roberts)

AoU Research Priorities Use Cases

How does genetic literacy influence and inform patient engagement, expectations and healthcare utilization efforts?

Genetic literacy can be defined as one's ability to understand concepts important to the use of personal genetic information. We propose that All of Us participants complete brief baseline survey items related to genetic literacy as part of the Participant-Provided Information (PPI; The Basics). We would explore the association between genetic literacy and outcomes such as patient engagement in All of Us, expectations... more »

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4 votes
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