(@jberghout)

AoU Research Priorities Use Cases

What are the best genetic indicators of wellness?

Wellness is not just absence of disease. But it is challenging to define aside from by disease exclusions. EHR data can't (easily) discriminate absent info. vs. evidence for absence of health concern. However, we (participants) know it when we feel it. Longitudinal data on self-reported "excellent" health, #minor illnesses/exacerb. (i.e. colds, non-critical injury, minor symptoms of chronic cond.), vital signs & etc can... more »

Voting

7 votes
Ideate
(@jberghout)

AoU Research Priorities Use Cases

What are the best genetic indicators of wellness?

Wellness is not just absence of disease. But it is challenging to define aside from by disease exclusions. EHR data can't (easily) discriminate absent info. vs. evidence for absence of health concern. However, we (participants) know it when we feel it. Longitudinal data on self-reported "excellent" health, #minor illnesses/exacerb. (i.e. colds, non-critical injury, minor symptoms of chronic cond.), vital signs & etc can... more »

Voting

7 votes
Ideate
(@cavin.ward)

AoU Research Priorities Use Cases

What are the molecular subtypes of hypertension?

Hypertension is a very common chronic disease that significantly increases risk of stroke and myocardial infarction. Though it's clinical definition is simple based on blood pressure it's molecular etiology is quite complex and poorly understood. This project would seek to identify genetic, epigenetic (DNA methylation), and metabolomic "subtypes" of hypertension both in isolation and as clusters. These subtypes may be... more »

Voting

7 votes
Ideate
(@blstone)

AoU Research Priorities Use Cases

Associations between genetics, environment, household, parenting time, and nutrition on early child development (ages 0-6)

Intensive data collection and analysis including genetic and epigenetic data over time, family history, physical environment (pollution, housing age, etc), social environment (income, household, employment/history, neighborhood, education resources, etc), nutrition, parenting (preparedness, skills, family composition, generational support, etc), early childhood stress, other exposures, demographics; to determine impact... more »

Voting

82 votes
Ideate
(@skbandt)

AoU Research Priorities Use Cases

Can we advance our understanding of epilepsy by developing new, data-driven tools for use in its diagnosis and treatment?

Gather MRI, genetic and basic clinical and behavioral data from all patients with epilepsy (conservatively 1% of the population). Data can then be analyzed using a machine learning approach to identify consistencies and differences among patients which can then inform our understanding of epilepsy subtypes and subsequent treatment decisions.

Voting

11 votes
Ideate
(@skbandt)

AoU Research Priorities Use Cases

Can we advance our understanding of epilepsy by developing new, data-driven tools for use in its diagnosis and treatment?

Gather MRI, genetic and basic clinical and behavioral data from all patients with epilepsy (conservatively 1% of the population). Data can then be analyzed using a machine learning approach to identify consistencies and differences among patients which can then inform our understanding of epilepsy subtypes and subsequent treatment decisions.

Voting

11 votes
Ideate
(@mera.babineaux)

AoU Research Priorities Use Cases

Does a parent’s passive nuclear exposure increase the risk for a child to have a chromosome defect?

Is there any correlation between nuclear exposure of a parent, through working in a nuclear facility or around radiation, and the diagnosis of chromosome defects in their biological offspring? This data could be collected utilizing existing patient records of children diagnosed with chromosome anomalies and surveying their parents’ exposure to radiation through their military service and employment records.

Voting

25 votes
Ideate
(@deesparacio)

AoU Research Priorities Use Cases

Use genetic sequencing to Identify what factors account for some individuals to live to 100 years without developing canc

Identify the population of individuals who are age 100 years half who may have had a cancer diagnosis and half with no cancer diagnosis in their lifetime. Survey those individuals as to their life experiences - medical history, employment history, lifestyle, exercise history, diet etc Individuals will provide a blood sample for complete genetic analysis. What genetic mutations are present which may cause cancer yet... more »

Voting

13 votes
Ideate
(@maggiematern)

AoU Research Priorities Use Cases

What genetic and environmental factors influence the progression of hearing loss in aging adults (presbycusis)?

The NIDCD estimates that age related hearing loss, or presbycusis, affects 1 in 3 individuals in the United States between 65 and 74 years old, and nearly half of those older than 75. Despite this large burden, few genetic risk factors have been identified, and it is unclear how genetics and environment interact to influence hearing loss susceptibility. I propose to measure hearing loss progression in the All of Us cohort,... more »

Voting

12 votes
Ideate
(@alan.sanders.md)

AoU Research Priorities Use Cases

Which genetic and environmental factors contribute to sexual orientation, and related health conditions?

Gays, lesbians, and bisexuals are underrepresented in biomedical research. While much relevant data is already planned for collection by AllofUs, additional or elaborated measures (see "data items") would help in seeking new leads and advancing work on pre-existing questions in the field. These items include sociodemographic (e.g., trait information), clinical (various associated conditions), and biological (genomic,... more »

Voting

30 votes
Ideate
(@dennis.ko)

AoU Research Priorities Use Cases

Determine how human genetic variation affecting cell biology impacts risk and severity of disease

Blood could be used to generate lymphoblastoid cell lines and induced pluripotent stem cells for deep phenotyping against exposures (toxins/pathogens/metabolites) and genome-wide association. Providing cells to the research community would result in an infinitely growing phenotypic catalog. For example, the cells could be tested for variation in susceptibility to flu. Integration of genomic/cellular/clinical data could... more »

Voting

4 votes
Ideate
(@ben.dorshorst)

AoU Research Priorities Use Cases

Is there a genetic component to conditions such as fibromyalgia, chronic pain, chronic fatigue, anxiety and depression?

Utilize existing health records, genomic and epigenomic data to identify factors that predispose or are otherwise associated with the conditions of fibromyalgia, chronic pain, chronic fatigue, anxiety and depression.

Voting

22 votes
Ideate
(@c.stillwell94)

AoU Research Priorities Use Cases

Are individuals with Down’s Syndrome more likely to be overweight or obese? If so, why? What can we do to help them? And how doe

Within the US there are numerous people with Down’s Syndrome. Most are overweight or obese. This research study would include finding out why individuals with Down’s are overweight and if it is because of a predisposing factor that cannot be controlled such as genetics or a modification made by the chromosomal editing. It will also look at, what ways we can help those individuals with weight needs. Discovering how individuals... more »

Voting

43 votes
Ideate

AoU Research Priorities Use Cases

frequent canker sores: what are the risk factors that predict how many episodes of canker sores per year a patient has

COLLECT DATA ON: which relatives also suffer from canker sores, collect data on how many canker sores per year people have, in motivated people, get a diary of each episode (how long it took to treat), what diet, what toothpaste, flossing frequency, canker sores after injury vs. from stress, treatment used ANALYZE: what factors can predict severe disease (age, gender, genetics), in a sub-cohort of severe canker sores... more »

Voting

4 votes
Ideate