Showing 33 ideas for tag "genetics"
(@mera.babineaux) kudos icon +

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Does a parent’s passive nuclear exposure increase the risk for a child to have a chromosome defect?

Is there any correlation between nuclear exposure of a parent, through working in a nuclear facility or around radiation, and the diagnosis of chromosome defects in their biological offspring? This data could be collected utilizing existing patient records of children diagnosed with chromosome anomalies and surveying their parents’ exposure to radiation through their military service and employment records.

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25 votes
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(@deesparacio) kudos icon +

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Use genetic sequencing to Identify what factors account for some individuals to live to 100 years without developing canc

Identify the population of individuals who are age 100 years half who may have had a cancer diagnosis and half with no cancer diagnosis in their lifetime.
Survey those individuals as to their life experiences - medical history, employment history, lifestyle, exercise history, diet etc
Individuals will provide a blood sample for complete genetic analysis.
What genetic mutations are present which may cause cancer yet... more »

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13 votes
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(@maggiematern) kudos icon +

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What genetic and environmental factors influence the progression of hearing loss in aging adults (presbycusis)?

The NIDCD estimates that age related hearing loss, or presbycusis, affects 1 in 3 individuals in the United States between 65 and 74 years old, and nearly half of those older than 75. Despite this large burden, few genetic risk factors have been identified, and it is unclear how genetics and environment interact to influence hearing loss susceptibility. I propose to measure hearing loss progression in the All of Us cohort,... more »

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12 votes
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(@alan.sanders.md) kudos icon +

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Which genetic and environmental factors contribute to sexual orientation, and related health conditions?

Gays, lesbians, and bisexuals are underrepresented in biomedical research. While much relevant data is already planned for collection by AllofUs, additional or elaborated measures (see "data items") would help in seeking new leads and advancing work on pre-existing questions in the field. These items include sociodemographic (e.g., trait information), clinical (various associated conditions), and biological (genomic,... more »

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30 votes
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(@dennis.ko) kudos icon +

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Determine how human genetic variation affecting cell biology impacts risk and severity of disease

Blood could be used to generate lymphoblastoid cell lines and induced pluripotent stem cells for deep phenotyping against exposures (toxins/pathogens/metabolites) and genome-wide association. Providing cells to the research community would result in an infinitely growing phenotypic catalog. For example, the cells could be tested for variation in susceptibility to flu. Integration of genomic/cellular/clinical data could... more »

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4 votes
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(@ben.dorshorst) kudos icon +

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Is there a genetic component to conditions such as fibromyalgia, chronic pain, chronic fatigue, anxiety and depression?

Utilize existing health records, genomic and epigenomic data to identify factors that predispose or are otherwise associated with the conditions of fibromyalgia, chronic pain, chronic fatigue, anxiety and depression.

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22 votes
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(@c.stillwell94) kudos icon +

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Are individuals with Down’s Syndrome more likely to be overweight or obese? If so, why? What can we do to help them? And how doe

Within the US there are numerous people with Down’s Syndrome. Most are overweight or obese. This research study would include finding out why individuals with Down’s are overweight and if it is because of a predisposing factor that cannot be controlled such as genetics or a modification made by the chromosomal editing. It will also look at, what ways we can help those individuals with weight needs. Discovering how individuals... more »

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43 votes
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frequent canker sores: what are the risk factors that predict how many episodes of canker sores per year a patient has

COLLECT DATA ON: which relatives also suffer from canker sores, collect data on how many canker sores per year people have, in motivated people, get a diary of each episode (how long it took to treat), what diet, what toothpaste, flossing frequency, canker sores after injury vs. from stress, treatment used

ANALYZE: what factors can predict severe disease (age, gender, genetics), in a sub-cohort of severe canker sores... more »

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4 votes
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(@nichd.allofus) kudos icon +

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What are the genetic and environmental risk factors that contribute to the broader autism phenotype in adolescents and adults?

To study genotype-phenotype correlations, utilize measures targeting the Broader Autism Phenotype: social and communication scales (SRS), Connors Rating Scale for ADHD, ratings of depressive symptoms (PHQ-9), anxiety disorders, & adverse childhood experiences (ACEs) & traumatic life events. Children transitioning to adulthood during the study will have repeat assessment of function and mental health status at a later... more »

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42 votes
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(@nichd.allofus) kudos icon +

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What genetic and environmental risk factors contribute to the development of pelvic organ prolapse (POP) as females age?

This study will focus on the entire cohort (menarche through lifespan) to collect data on general health and wellbeing as well as detailed pregnancy & delivery histories. Activity level will be monitored, specifying any straining associated with either physical activity or occupation. Genetic/epigenetic factors, such as family history of POP or connective tissue disorders will be obtained, as will data on other currently... more »

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25 votes
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(@nichd.allofus) kudos icon +

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What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?

This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations... more »

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43 votes
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(@nichd.allofus) kudos icon +

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What risk factors predispose children to sepsis, and what interventions are most effective for prevention and treatment?

This study will focus on the entire cohort of children (infants-18 y/o) and will identify those risk factors which predispose children to sepsis. The information will be used to create more precise strategies to identify individuals at highest risk of sepsis and to implement preventive or early treatment therapies that would improve outcomes. The study will also assess the use of adjunctive immunomodulatory therapies... more »

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35 votes
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(@nichd.allofus) kudos icon +

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What are the unique factors associated with early onset obesity in different ethnic and racial groups?

This study will focus on women who are pregnant when they enroll, or become pregnant during the study, in order to follow their infants from birth to 8 years of age to determine trajectories of growth over time and identify genomic and epigenomic factors related to development of obesity. Critical to obtaining this information will be the review of Electronic Health Records of providers who have the correct measuring... more »

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155 votes
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(@nichd.allofus) kudos icon +

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How do genetic factors of ADHD influence treatment strategies? Can they affect success of treatment or the choice of therapy?

Screen school-age children for ADHD by testing, if feasible, or by electronic health record search. Perform WGS on children as the preferred strategy to identify new genetic associations and confirm previously reported genetic associations. If WGS is not possible, develop a marker panel and test children who have ADHD for known or suspected genetic factors. Follow children by periodic medical evaluations and school performance... more »

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94 votes
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(@nichd.allofus) kudos icon +

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What factors are involved in loss of fecundity in males and females?

This study will focus on the entire cohort across the reproductive lifespan (ages 12-55) collecting data on fertility (time to conception) and pregnancy loss. Additional data will include factors believed to be indicators of fertility as determined by questionnaire, blood tests, factors believed to negatively impact fertility, and genetic/epigenetic data that together may provide new targets for understanding oocyte depletion,... more »

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29 votes
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