(@mbl2018)

AoU Research Priorities Use Cases

How do our mindsets about diet, exercise, and stress influence health behaviors and health outcomes?

Research has shown that benefits of health behaviors such as diet, exercise, and stress depend not just on the behaviors themselves but on the mindsets people have about those behaviors (Crum, Achor & Salovey, 2013; Zahrt & Crum 2017; Turnwald, Boles & Crum 2017); however, large-scale databases have not yet included measures of mindset. The goal of this study is to use validated measures of exercise, stress and diet mindsets... more »

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(@katiew)

AoU Research Priorities Use Cases

Risk and protective factors for alcohol and other drug use disorders, as well as associated health outcomes.

More than 1 in 5 Americans meet lifetime criteria for alcohol use disorder and 1 in 10 Americans meet lifetime criteria for a drug use disorder. Most individuals never seek treatment and most reduce their alcohol or drug use in the absence of treatment. Research on the biological, psychological, and social risk factors for developing and recovering from alcohol/drug use disorders is critical. Annual assessments of DNAm,... more »

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1 vote
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(@gerhild.ullmann)

AoU Research Priorities Use Cases

What are the health benefits of mind-body exercises such as Feldenkrais, tai chi, yoga etc.?

Health benefits of mind-body exercises are 'under-researched' compared to health benefits of aerobic exercises. Many people do not meet the current physical activity recommendations for maintaining health, in particular older adults and individuals with chronic health issues. Thus, it is of high importance to facilitate the potential health effects of mind-body exercises. Funding for well-designed randomized controlled... more »

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1 vote
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AoU Research Priorities Use Cases

How do contract and contingent (temporary) work arrangements affect worker health?

More than 90% of all job growth in the US from 2005-2015 occurred in “alternative work arrangements” (e.g., part-time or contract work). This has provided flexible employment opportunities, but negative effects on health. AoU could look at how contract and contingent workers cope with job insecurity, lack of health and retirement benefits, and absence of job safety policies and training, and how these affect mental health,... more »

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1 vote
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(@lisa.signorello)

AoU Research Priorities Use Cases

To develop/refine novel technologies (related to GPS or GIS) that could help us better define community contextual exposures.

The built environment is only one contextual exposure of interest to investigators who study these factors in relation to disease (and even these function variably across rural and urban areas). New technology could assist in better clarifying a fuller scope of residential exposures, including what elements/exposures the All of Us participants actually come into contact with.

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1 vote
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(@lisa.signorello)

AoU Research Priorities Use Cases

To develop or optimize a non-invasive BIOMARKER that can be used to measure the experience of stress in children and adults.

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

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3 votes
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(@sachdevv)

AoU Research Priorities Use Cases

Using mobile technologies to empower heart failure patients to self-monitor and participate in disease management

Management of heart failure involves attention to salt/fluid intake, control of blood pressure, and daily weight monitoring. Physical activity has been shown to reduce hospitalizations in patients with reduced cardiac function and it may also play a role in diastolic heart failure. Recording data on home-measured parameters and linking them to cardiac outcomes will provide information on optimal methods for use of mobile... more »

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10 votes
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(@laura.dwyer)

AoU Research Priorities Use Cases

How does the social environment contribute to health behaviors and outcomes within intimate relationships?

There is insufficient knowledge about relationship-level factors in couples to adequately inform precision behavior change interventions. Existing interventions largely do not account for how the social environment contributes to lifestyle behaviors and that these behaviors are often done with others, or in response to our relationships (i.e., couples). The All of Us cohort presents a unique opportunity to survey cohort... more »

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4 votes
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(@troianor)

AoU Research Priorities Use Cases

How are sleep, sedentary behavior and physical activity related to one another, and interactively, related to health?

Sleep (quantity, quality, timing), sedentary behavior, and physical activity of various intensities, affect each other and many health outcomes. Health conditions affect individuals’ sleep and activity patterns. Capturing 24-hour device data repeatedly will allow exploration of multiple hypotheses about sleep, sedentary behavior, physical activity and health. Longitudinal data will allow exploration of causality in both... more »

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27 votes
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(@troianor)

AoU Research Priorities Use Cases

How are sleep, sedentary behavior and physical activity related to one another, and interactively, related to health?

Sleep (quantity, quality, timing), sedentary behavior, and physical activity of various intensities, affect each other and many health outcomes. Health conditions affect individuals’ sleep and activity patterns. Capturing 24-hour device data repeatedly will allow exploration of multiple hypotheses about sleep, sedentary behavior, physical activity and health. Longitudinal data will allow exploration of causality in both... more »

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27 votes
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(@jaime.gahche)

AoU Research Priorities Use Cases

Why assess diet and dietary supplements in the population?

Over half of US adults and one-third of children take at least one dietary supplement. Combined with intakes of foods, total nutrient intake can be estimated and linked to health outcomes in etiologic research. Such population data can inform guidance, such as the Dietary Guidelines for Americans and Dietary Reference Intakes. Supplements may be warranted for sub-groups where nutritional requirements may not be met through... more »

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5 votes
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(@riscutag2)

AoU Research Priorities Use Cases

Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

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19 votes
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(@riscutag2)

AoU Research Priorities Use Cases

Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

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19 votes
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(@jenna.norton)

AoU Research Priorities Use Cases

Can inclusion of erectile dysfunction (ED) improve prediction of incident cardiovascular disease (CVD)?

Recent epidemiological evidence shows ED is associated with CVD, suggesting ED may be a prodrome of CVD. We proposed to assess associations between ED preceding CVD to confirm this association in the large and diverse All of Us cohort. Additionally, ED will be added to the existing Framingham risk prediction equation to determine if inclusion of ED improves the model.

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7 votes
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