(@lisa.signorello)

AoU Research Priorities Use Cases

To what extent are adverse childhood experiences (ACE) or trauma related to a wide range of adult diseases or premature death?

Adverse childhood experiences (ACE) can be retrospectively assessed in adults, ideally before the onset of the diseases under study. There are existing ACE instruments, or attempts to refine these instruments could be undertaken within All of Us.

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5 votes
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(@lisa.signorello)

AoU Research Priorities Use Cases

To develop or optimize a non-invasive BIOMARKER that can be used to measure the experience of stress in children and adults.

The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine biomarkers that could help push this field of research forward in a valid way for the future. Such biomarkers could be a part of individual studies of stress and disease, and could also be used as a gold standard to develop... more »

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3 votes
Ideate
(@sachdevv)

AoU Research Priorities Use Cases

Using mobile technologies to empower heart failure patients to self-monitor and participate in disease management

Management of heart failure involves attention to salt/fluid intake, control of blood pressure, and daily weight monitoring. Physical activity has been shown to reduce hospitalizations in patients with reduced cardiac function and it may also play a role in diastolic heart failure. Recording data on home-measured parameters and linking them to cardiac outcomes will provide information on optimal methods for use of mobile... more »

Voting

10 votes
Ideate

AoU Research Priorities Use Cases

Can the recycling of influenza viruses explain changes in phenotypes of CHD cases?

I proposed that the 1950s-60s CHD deaths were associated with H1-H2 Influenza A re-infectiosn of H3 Influenza primed individuals (born around 1890). After 1968, when the H3 influenza virus returned, high serum cholesterol CHD cases declined and a second atherogenic phenotype emerged (H3 re-infection of H1-primed cohorts born after 1900 and more after 1918?). Would CHD mortality with high serum cholesterol levels increase... more »

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1 vote
Ideate
(@wye000)

AoU Research Priorities Use Cases

What is the long-term comparative effectiveness of empagliflozin in a heterogeneous population with type 2 diabetes?

Empaglifozin, a highly selective sodium-glucose cotransport 2 (SGLT2) inhibitor, has been shown to significantly reduce major adverse cardiovascular (CV) events and hospitalization for heart failure in patients with type 2 diabetes (T2DM) and established CV disease. The generalizability of this finding to lower risk population is unknown. We propose to compare cardiovascular outcomes in a more heterogeneous population... more »

Voting

3 votes
Ideate
(@wye000)

AoU Research Priorities Use Cases

What is the long-term comparative effectiveness of empagliflozin in a heterogeneous population with type 2 diabetes?

Empaglifozin, a highly selective sodium-glucose cotransport 2 (SGLT2) inhibitor, has been shown to significantly reduce major adverse cardiovascular (CV) events and hospitalization for heart failure in patients with type 2 diabetes (T2DM) and established CV disease. The generalizability of this finding to lower risk population is unknown. We propose to compare cardiovascular outcomes in a more heterogeneous population... more »

Voting

3 votes
Ideate
(@changhu)

AoU Research Priorities Use Cases

What are the long-term cardiovascular effects of cancer therapy? Do childhood cancer survivors have reduced cardiac functions?

To study adult cancer survivors who received cancer therapy during childhood. What are their cardiovascular functions as compared to adults who did not receive cancer therapy. Reduction of cardiovascular functions after anticancer therapy may take years to develop. These undesirable complications can compromise quality of life or shorten life span. This study will provide evidence-based guidelines for physicians to choose... more »

Voting

17 votes
Ideate
(@changhu)

AoU Research Priorities Use Cases

What are the long-term cardiovascular effects of cancer therapy? Do childhood cancer survivors have reduced cardiac functions?

To study adult cancer survivors who received cancer therapy during childhood. What are their cardiovascular functions as compared to adults who did not receive cancer therapy. Reduction of cardiovascular functions after anticancer therapy may take years to develop. These undesirable complications can compromise quality of life or shorten life span. This study will provide evidence-based guidelines for physicians to choose... more »

Voting

17 votes
Ideate
(@ginawei)

AoU Research Priorities Use Cases

Develop more accurate and clinically relevant sub-classification/phenotyping of heart failure

Heart failure (HF), though relatively common in U.S. adults, can be thought of as a syndrome with many subtypes that require different treatments. All of Us provides a rich platform on which to collect more data (e.g., novel biomarkers and imaging studies) on HF patients. This, coupled with AoU’s existing rich genomics, behavioral, and clinical data, can be analyzed to refine the phenotyping and sub-classification of... more »

Voting

9 votes
Ideate
(@ginawei)

AoU Research Priorities Use Cases

Identify and create a cohort of heart failure patients within All of Us to enable discovery and clinical research

Prevalence of heart failure (HF) in U.S. has risen to ~6.1 million among those ≥20 years of age. AoU provides a rich platform to identify HF patients through EHR (including clinical laboratory and imaging reports) and claims data. Ability to follow and collect data prospectively in the patients, including ancillary studies of more surveys and imaging/biomarker collections, could advance discovery science and address... more »

Voting

9 votes
Ideate
(@changhu)

AoU Research Priorities Use Cases

What are the genetic, comorbid risk factors, and anticancer agents that contribute to heart failure after cancer therapy

Goals:To study the epidemiology of cardiovascular complications of cancer therapy in order to design prevention strategy and precision treatment of cancer patients while minimizing debilitating cardiovascular complications. Methods: compare data on genetic, co morbid risk factors, and anticancer agents used in association with cardiovascular complications after cancer therapy. Expected outcomes: This study will provide... more »

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11 votes
Ideate