The built environment is only one contextual exposure of interest to investigators who study these factors in relation to disease (and even these function variably across rural and urban areas). New technology could assist in better clarifying a fuller scope of residential exposures, including what elements/exposures the All of Us participants actually come into contact with.
The impact of psychosocial stress on child and adult health risk is increasingly appreciated. The measurement of this exposure is currently poor, and All of Us has the opportunity to develop or refine wearable technologies that could help push this field of research forward in a valid way for the future. Such technology could be a part of individual studies of stress and disease, and could also be used as a gold standard... more »
There are strong areal relationships with the rate of heart disease. the Allofus design can help distinguish individual genetic risk and behaviors from the role of social factors. it is essential, however, that the data set include sufficient areal data and information (such as zip code and census track) to support such analyses. The information that links to societal level data needs to be collected repeatedly and... more »
The American College of Cardiology/American Heart Association Atherosclerotic Cardiovascular Disease risk score is a well-known and widely used risk score that provides 10-year risk estimates. However, this score does not account for environmental exposures as experienced at a person's primary residence, many of which are strongly associated with cardiovascular disease. Using All of Us we can evaluate if measurements... more »
Blood pressure and anti-hypertensive medication use will be collected at baseline through physical examination and medical history taking as well as from the EHR. Track blood pressure and changes in medication to examine different regimens and degrees of blood pressure control as predictors of vascular complications, while using continuing medical care to understand the role of potential co-morbidities and medication... more »
Every year over one million heart catheterizations are performed in the United States alone. This study would aim to find if these procedures truly benefit the patient or if they are unnecessarily performed. In order to get accurate results the study would need to take place over a 3-5 year time frame comparing those who had the procedure and those who elected to forgo. The study would monitor the subjects' cardiac-related... more »