(@lisa.signorello)

AoU Research Priorities Use Cases

How does chronic stress influence the persistence of oncogenic viruses or bacteria in otherwise healthy adults?

Chronic stress has significant suppressive impact on the immune system and would influence the risk of infection-associated cancers if high risk infections are allowed to persist. In general populations and healthy adult populations, this question has not been addressed. It would involve serial measurement of oral or anogenital human papillomavirus, or even helicobacter pylori.

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(@lisa.signorello)

AoU Research Priorities Use Cases

How does chronic stress influence the persistence of oncogenic viruses or bacteria in otherwise healthy adults?

Chronic stress has significant suppressive impact on the immune system and would influence the risk of infection-associated cancers if high risk infections are allowed to persist. In general populations and healthy adult populations, this question has not been addressed. It would involve serial measurement of oral or anogenital human papillomavirus, or even helicobacter pylori.

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2 votes
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(@lhwostow001)

AoU Research Priorities Use Cases

Conduct research to determine if blood can help identify the presence of the HPV-16 virus.

Goal: save millions of lives. A person dies from oral cancer every hour of every day. Methodology: - Include people diagnosed with oral and oropharyngeal cancer caused by the HPV-16 virus - Collect and analyze blood every 3 months within the first 2 years of diagnosis. Between 2 and 5 years do it every 4 months Outcome: increase the survival rate. The death rate is about 43% at five years from diagnosis. When found at... more »

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3 votes
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(@lhwostow001)

AoU Research Priorities Use Cases

Conduct research to determine if blood can help identify the presence of the HPV-16 virus.

Goal: save millions of lives. A person dies from oral cancer every hour of every day. Methodology: - Include people diagnosed with oral and oropharyngeal cancer caused by the HPV-16 virus - Collect and analyze blood every 3 months within the first 2 years of diagnosis. Between 2 and 5 years do it every 4 months Outcome: increase the survival rate. The death rate is about 43% at five years from diagnosis. When found at... more »

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3 votes
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(@jatkinso)

AoU Research Priorities Use Cases

What genetic factors are associated with oral cancer (OC) and oropharyngeal cancer (OPC)?

Tobacco and alcohol use and persistent oral infection with human papillomavirus (HPV) are risk factors for oral cancer (OC) and oropharyngeal cancer (OPC). CDC estimates that approximately 60% of OPC cases in the United States are caused by HPV types 16/18. Previous studies (GWAS) suggest genetic factors are associated with an increased risk of developing HPV-related OPCs. Assessing genetic factors in a large population... more »

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