AoU Research Priorities Use Cases

Genetic, epigenetic, and microbiome contributions to hypertension

The goal would be to enhance our understanding of how social and environmental exposures, genomic factors, and gut microbiota interact to influence hypertension susceptibility and phenotype. This would require integrated analyses of genomic and other -omics data, exposures, and phenotype data, and could lead to insights that enable more targeted prevention and treatment. Inherent in this would be discovery of pathways... more »

Voting

6 votes
Ideate
(@cavin.ward)

AoU Research Priorities Use Cases

What are the molecular subtypes of hypertension?

Hypertension is a very common chronic disease that significantly increases risk of stroke and myocardial infarction. Though it's clinical definition is simple based on blood pressure it's molecular etiology is quite complex and poorly understood. This project would seek to identify genetic, epigenetic (DNA methylation), and metabolomic "subtypes" of hypertension both in isolation and as clusters. These subtypes may be... more »

Voting

7 votes
Ideate
(@cavin.ward)

AoU Research Priorities Use Cases

What are the molecular subtypes of hypertension?

Hypertension is a very common chronic disease that significantly increases risk of stroke and myocardial infarction. Though it's clinical definition is simple based on blood pressure it's molecular etiology is quite complex and poorly understood. This project would seek to identify genetic, epigenetic (DNA methylation), and metabolomic "subtypes" of hypertension both in isolation and as clusters. These subtypes may be... more »

Voting

7 votes
Ideate

AoU Research Priorities Use Cases

What hypertension medicine regimen is most effective to prevent complications (kidney, heart, and brain) over the lifecourse?

Blood pressure and anti-hypertensive medication use will be collected at baseline through physical examination and medical history taking as well as from the EHR. Track blood pressure and changes in medication to examine different regimens and degrees of blood pressure control as predictors of vascular complications, while using continuing medical care to understand the role of potential co-morbidities and medication... more »

Voting

8 votes
Ideate
(@sthompson1)

AoU Research Priorities Use Cases

Impact of persistent hypervolemia on development of hypertension and heart failure

It has been posited that hypertension is due to excess blood volume or vasoconstriction, but hypertension therapy trials have looked at specific doses of diuretic or vasodilator. The question to answer is: Does individualization of therapy for patient-specific hypertension improve outcomes and possibly avert onset of heart failure? Patients receiving treatment for hypertension could received direct blood volume tests... more »

Voting

3 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What genetic markers predict consequences of pregnancy associated hypertension & gestational diabetes for mothers & offspring?

This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.

Voting

26 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What genetic markers predict consequences of pregnancy associated hypertension & gestational diabetes for mothers & offspring?

This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.

Voting

26 votes
Ideate