(@dennis.ko)

AoU Research Priorities Use Cases

Determine how human genetic variation affecting cell biology impacts risk and severity of disease

Blood could be used to generate lymphoblastoid cell lines and induced pluripotent stem cells for deep phenotyping against exposures (toxins/pathogens/metabolites) and genome-wide association. Providing cells to the research community would result in an infinitely growing phenotypic catalog. For example, the cells could be tested for variation in susceptibility to flu. Integration of genomic/cellular/clinical data could... more »

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(@raodiv)

AoU Research Priorities Use Cases

Role of Persistent Co-infections in Health and Disease

Co-infections can significantly alter disease risk, incidence, prevalence, aggressiveness, treatment response and outcomes, in addition to, making it more difficult to manage and treat the diseases. Compare differences in host response to co-infections, disease risk and treatment response to elucidate how the ubiquitous co-infections contribute to variations in disease incidence and outcomes.

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