Chronic stress has significant suppressive impact on the immune system and would influence the risk of infection-associated cancers if high risk infections are allowed to persist. In general populations and healthy adult populations, this question has not been addressed. It would involve serial measurement of oral or anogenital human papillomavirus, or even helicobacter pylori.
Stress urinary incontinence (SUI) is prevalent among women, yet the standard of care treatment – midurethral mesh sling – can lead in devastating mesh complications (dyspareunia that precludes sex, chronic pelvic pain, infection). Using national data, we will identify biological (eg, genomics, vaginal & urinary microbiome, race, comorbidities, metabolic syndrome) and behavioral (eg, smoking, physical activity) factors... more »
Antibiotics have long been the standard of care for treatment of urinary tract infections (UTI). However, UTI may be successfully managed without antibiotics, thereby reducing unnecessary contributions to antibiotic resistance. We proposed to compare outcomes (e.g., pyelonephritis, sepsis, GI distress/ diarrhea) in individuals with UTI treated with and without antibiotics, controlling for potential confounders (infection... more »