Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »
Precision microbiome engineering could be applied to vaccine delivery, immunology, drug-resistant infections, and post-surgical infections. Specific research questions re pathogenesis and treatment: - What aspects of the indigenous microbiota mediate colonization resistance against C. difficile, as well as other multi-drug resistant organisms such as carbapenamase-producing gram negative bacteria and vancomycin resistant... more »
How is precision medicine as it applies to infectious diseases different than how it is considered for Oncology or other fields?
• Time-pressured setting (e.g., initiating therapy for a hospital acquired or ventilator-associated bacterial pneumonia patient)
• Microbiome vs. human genome
• Intersections with other cognitive and procedural specialties across the board
Key areas of unmet medical need: - Improve identification of patients at high risk for sepsis - Improve characterization of patients with sepsis (endotyping) - Predict outcomes of acute infections and/or sepsis at the time of presentation - Develop companion diagnostics (biomarkers?) that identify patients responding to specific sepsis therapies - Improve early diagnosis of pathogens causing sepsis and their resistance... more »
Goals: To determine if women are more susceptible to infections and autoimmune diseases around the period of childbirth. To determine if infectious diseases like Lyme Disease are a precipitating factor for other diseases like scleroderma. Participants: Females of childbearing age Data: Genetic, Environmental, Lab work, Pain assessments, Any factors that could moderate outcomes. Frequency of data: monthly ? during pregnancy... more »