AoU Research Priorities Use Cases

AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »

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AoU Research Priorities Use Cases

Using human microbiome data to improve pathogenesis and treatment of infectious diseases

Precision microbiome engineering could be applied to vaccine delivery, immunology, drug-resistant infections, and post-surgical infections. Specific research questions re pathogenesis and treatment: - What aspects of the indigenous microbiota mediate colonization resistance against C. difficile, as well as other multi-drug resistant organisms such as carbapenamase-producing gram negative bacteria and vancomycin resistant... more »

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AoU Research Priorities Use Cases

How can AoU data be harnessed to improve infectious diseases patient care, diagnostics, vaccinolology, and drug development?

How is precision medicine as it applies to infectious diseases different than how it is considered for Oncology or other fields?

• Time-pressured setting (e.g., initiating therapy for a hospital acquired or ventilator-associated bacterial pneumonia patient)

• Microbiome vs. human genome

• Intersections with other cognitive and procedural specialties across the board

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AoU Research Priorities Use Cases

Improving precision management of acute infections and sepsis as a major burden to healthcare systems

Key areas of unmet medical need: - Improve identification of patients at high risk for sepsis - Improve characterization of patients with sepsis (endotyping) - Predict outcomes of acute infections and/or sepsis at the time of presentation - Develop companion diagnostics (biomarkers?) that identify patients responding to specific sepsis therapies - Improve early diagnosis of pathogens causing sepsis and their resistance... more »

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AoU Research Priorities Use Cases

What is the relationship between pregnancy-childbirth-and post-partum immune system functioning and autoimmune disorders?

Goals: To determine if women are more susceptible to infections and autoimmune diseases around the period of childbirth. To determine if infectious diseases like Lyme Disease are a precipitating factor for other diseases like scleroderma. Participants: Females of childbearing age Data: Genetic, Environmental, Lab work, Pain assessments, Any factors that could moderate outcomes. Frequency of data: monthly ? during pregnancy... more »

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