(@mbl2018)

AoU Research Priorities Use Cases

How do mindsets about illness & treatment affect biomarkers of inflammation & treatment outcomes in patients w/ chronic illness?

Half of all Americans are diagnosed with one or more chronic illnesses, like heart disease and cancer. Mindsets about these illnesses may have a profound impact on the diagnosis, progression, and treatment of these illnesses. This study aims to: (1) understand the distribution of mindsets held by a diverse group of both healthy and chronically ill Americans, and (2) identify relationships between these mindsets, biomarkers... more »

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(@judithjames808)

AoU Research Priorities Use Cases

How do inflammation and subclinical autoimmunity impact adverse reproductive health?

Preterm delivery is a serious problem. SLE and RA patients have increased pregnancy morbidity before diagnosis and their healthy sisters have increased rates of pregnancy complications. Therefore, pre-clinical autoimmunity or inflammation may affect pregnancy outcomes. Reproductive and family history, and rheumatic disease symptoms, would be collected and correlated with hsCRP levels and autoantibody production in a... more »

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(@judithjames808)

AoU Research Priorities Use Cases

How do inflammation and subclinical autoimmunity impact adverse reproductive health?

Preterm delivery is a serious problem. SLE and RA patients have increased pregnancy morbidity before diagnosis and their healthy sisters have increased rates of pregnancy complications. Therefore, pre-clinical autoimmunity or inflammation may affect pregnancy outcomes. Reproductive and family history, and rheumatic disease symptoms, would be collected and correlated with hsCRP levels and autoantibody production in a... more »

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AoU Research Priorities Use Cases

AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »

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(@mgough)

AoU Research Priorities Use Cases

What are the social and environmental stressors that lead to changes in aging, as detected in bone mineral density?

Social and environmental factors (e.g., poverty, strain, environmental toxins) may affect the risk of premature aging as measured through bone density, and they may be linked to measures of inflammation. Data are needed on markers of inflammation, stress processes, bone density, subjective and objective environmental data, measures of social support and strain, detailed measures of socioeconomic status, measures of state... more »

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(@mgough)

AoU Research Priorities Use Cases

What are the social and environmental stressors that lead to changes in aging, as detected in bone mineral density?

Social and environmental factors (e.g., poverty, strain, environmental toxins) may affect the risk of premature aging as measured through bone density, and they may be linked to measures of inflammation. Data are needed on markers of inflammation, stress processes, bone density, subjective and objective environmental data, measures of social support and strain, detailed measures of socioeconomic status, measures of state... more »

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(@robynbjork)

AoU Research Priorities Use Cases

Do new MLD techniques reduce tissue inflammation, promote connective tissue remodeling, and lymph capillary regeneration?

Edema volume reduction has been used as a benchmark for showing improvements with lymphedema treatment, but equally important is the remodeling of skin and connective tissue to a more normalized state. This study aims to assess and track skin and subcutaneous tissue inflammation, connective tissue remodeling, and lymph capillary regeneration as a result of new manual lymphatic drainage techniques.

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2 votes
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(@ruthi10032)

AoU Research Priorities Use Cases

Bridging the gap between obstetric history (preeclampsia) and future women's health and cardiovascular outcomes

2 possible designs: 1) Enroll women diagnosed with preeclampsia (PEC) during current pregnancy and collect data (phenotype & biomarkers), follow up prospectively until cardiovascular events (acute coronary events, strokes, including cardiac surgery) 2) Ambidirectional design: enroll women with a PEC history now having cardiac surgery/cardiopulmonary bypass (CPB); collect biomarkers & clinical outcomes (phenotype after... more »

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(@carterrob)

AoU Research Priorities Use Cases

How do autoimmune diseases start?

Many autoimmune diseases are characterized by the presence of autoantibodies. These may be present long before disease starts, but what triggers the transition from autoimmunity (the presence of the antibodies) to disease is unknown, but is likely to include both environmental exposures and genetic susceptibility. What are the risk factors for the transition to disease? Are these modifiable? In which patients is the risk... more »

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