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What are the future outcomes for people who present with REM sleep behavior disorder (physically acting out dreams while asleep)

REM sleep behaviour (RBD) can precede subsequent Lewy body disease by many years/decades. Thus RBD could be a potent prodromal biomarker of future disease and allow for identification of an ideal target population for disease modifying treatment. In depth assessment of sleep behaviours in midlife as measured using participant survey complimented by wearable devices technology could provide unparalleled information in ...more »

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AoU Research Priorities Use Cases

What midlife lifestyle factors make someone more or less likely to develop dementia with Lewy bodies?

Exercise, socialization, cognitive training, education, dietary habits and environmental exposures interacting with genetic profiles are suggested to raise the risk of Alzheimer’s dementia. Less is known about environmental, genetic and epigenetic contributors to raising the risk of dementia with Lewy bodies. Large scale data sets would allow first-of-its-kind enhanced profiling in multi-path analyses key midlife factors ...more »

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What are the future neurodegenerative outcomes for people who develop hyposmia, anosmia or chronic constipation?

These are frequent antecedents in neurodegenerative disease. They may, in themselves, be early biomarkers and or demarcate a peripheral origin for the disease. However their onset is not well understood and they are not specific to neurodegenerative diseases. Understanding their natural history, and co-association with other midlife/old age symptoms coupled with omic data may help understand the role of these symptoms ...more »

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