Complex diseases are a result of a complex interplay of genetic, environmental, host and societal factors operating over a prolonged time. Many factors associated with disease onset or progression have been elucidated using a silo-ed approach which fails to adequately assess interplay between factors. Longitudinal measures and more sophisticated analytical methods are needed to support comprehensive (e.g. systems or computational... more »
Clinical evidence suggests that cancer survivors, people living with HIV/AIDS, and diabetics may age prematurely from treatment toxicity. The All of Us study could be used to study these observatons over time by comparing aging trajectories and risk factors for individuals with and without systemic therapy use and investigate the mechanisms that cause alterations in the rate or way individuals age.