AoU Research Priorities Use Cases

Do work conditions underlie disparities in maternal mortality, preterm birth, and breastfeeding?

Over half of U.S. births occur to working women. A woman’s job dictates her ability to take leave for prenatal and postnatal care, to remain off work after the birth to heal and care for the baby, and to continue to breastfeed her baby through the first year of life. The All of Us study will allow researchers to determine what workplace factors are strengths and barriers to optimal health for both mother and baby, and ...more »

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1 vote
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(@steffleonard)

AoU Research Priorities Use Cases

How do maternal health complications affect the long-term health of women and outcomes in subsequent pregnancies?

Severe maternal morbidities are rare, but increasing in the U.S., and the causes and long-term consequences are poorly understood. All of Us would provide a study population with enough participants, detail, and follow-up time to thoroughly investigate how complications during pregnancy, delivery, and postpartum affect future health in women and their children to inform prevention of negative outcomes, such as cardiovascular ...more »

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16 votes
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(@alan.sanders.md)

AoU Research Priorities Use Cases

Which genetic and environmental factors contribute to sexual orientation, and related health conditions?

Gays, lesbians, and bisexuals are underrepresented in biomedical research. While much relevant data is already planned for collection by AllofUs, additional or elaborated measures (see "data items") would help in seeking new leads and advancing work on pre-existing questions in the field. These items include sociodemographic (e.g., trait information), clinical (various associated conditions), and biological (genomic, ...more »

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30 votes
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(@nichd.allofus)

AoU Research Priorities Use Cases

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

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120 votes
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(@nichd.allofus)

AoU Research Priorities Use Cases

What are the long-term effects and risks of opioid use disorder during pregnancy on maternal and child health?

This study will focus on the entire cohort. The goal will be to determine the interaction of genomic, sociodemographic, physiologic and environmental factors for the mother and child impacted by Neonatal Opioid Withdrawal Syndrome (NOWS) and their impact on treatment response, treatment outcome, health outcomes for the mother, and developmental outcomes for the child.

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120 votes
Ideate