(@steffleonard)

AoU Research Priorities Use Cases

How do maternal health complications affect the long-term health of women and outcomes in subsequent pregnancies?

Severe maternal morbidities are rare, but increasing in the U.S., and the causes and long-term consequences are poorly understood. All of Us would provide a study population with enough participants, detail, and follow-up time to thoroughly investigate how complications during pregnancy, delivery, and postpartum affect future health in women and their children to inform prevention of negative outcomes, such as cardiovascular... more »

Voting

16 votes
Ideate
(@steffleonard)

AoU Research Priorities Use Cases

How do maternal health complications affect the long-term health of women and outcomes in subsequent pregnancies?

Severe maternal morbidities are rare, but increasing in the U.S., and the causes and long-term consequences are poorly understood. All of Us would provide a study population with enough participants, detail, and follow-up time to thoroughly investigate how complications during pregnancy, delivery, and postpartum affect future health in women and their children to inform prevention of negative outcomes, such as cardiovascular... more »

Voting

16 votes
Ideate
(@acaple07)

AoU Research Priorities Use Cases

Could regular screening for postpartum for up to a year after birth decrease postpartum depression?

I would select women who has just given birth or have children ranging from 3 months, 6 months, and 9 months to get a postpartum screening done every three months to see if they have any signs of postpartum. The outcome is to see what and how the mother is feeling in the different milestones of the child's life as well as their own. What effects does it have on both the mother and the child

Voting

57 votes
Ideate
(@pgejman)

AoU Research Priorities Use Cases

Do blood biomarkers predict mood transitions for peripartum mood disorder (PPMD)?

Mood disorder in pregnant and postpartum women is common, often severe, but frequently undiagnosed and untreated, and largely understudied. I propose to augment the AllofUs protocol for research into PPMD by adding collection of biospecimens for OMIC measurements at fixed times relative to pregnancy, and also when triggered by alerts of critical clinical mood state shifts as informed by wearable technology or computerized... more »

Voting

14 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What characteristics distinguish a healthy maternal pregnancy-microbiome from one that experienced microbial perturbations?

This study will focus on a subsample of all pregnant women and follow them throughout pregnancy to obtain serial assessments and measurements, including laboratory microbiologic evaluation testing of oral, skin and vaginal specimens. Follow-up would end at delivery of the infant; serial pregnancies would be eligible to re-enroll. Assessments and measures would be used along with health outcomes to determine associations... more »

Voting

43 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What genetic markers predict consequences of pregnancy associated hypertension & gestational diabetes for mothers & offspring?

This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.

Voting

26 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What genetic markers predict consequences of pregnancy associated hypertension & gestational diabetes for mothers & offspring?

This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.

Voting

26 votes
Ideate