(@lisa.signorello)

AoU Research Priorities Use Cases

To what extent are adverse childhood experiences (ACE) or trauma related to a wide range of adult diseases or premature death?

Adverse childhood experiences (ACE) can be retrospectively assessed in adults, ideally before the onset of the diseases under study. There are existing ACE instruments, or attempts to refine these instruments could be undertaken within All of Us.

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(@mveenker)

AoU Research Priorities Use Cases

What are the connections exist between comorbid brain disorders such as epilepsy and bipolar disorder and MS?

Too many people have comorbid brain disorders. Not enough is known each disease independently, what causes them and what, if anything, contributes to resilience in the rest of us who do not suffer from them. Research on familial links, people with similar comorbid brain disorders, genetics that play into who gets these diseases and how individuals react uniquely to medications can all lead us to a better understanding,... more »

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