(@svogelstein)

AoU Research Priorities Use Cases

What etiology factors contribute to the onset of seizures in late adulthood?

The incidence of seizures increases after the age of 50 years. With the increased life expectancy, seizures in older adults represents an emerging and important public health concern. Although cerebrovascular disease contributes to some cases, the etiology of these seizures in most patients is large known. Metabolic factors are likely to contribute to risk in some patients as diet changes can reduce the frequency of seizures... more »

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3 votes
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(@svogelstein)

AoU Research Priorities Use Cases

What etiology factors contribute to the onset of seizures in late adulthood?

The incidence of seizures increases after the age of 50 years. With the increased life expectancy, seizures in older adults represents an emerging and important public health concern. Although cerebrovascular disease contributes to some cases, the etiology of these seizures in most patients is large known. Metabolic factors are likely to contribute to risk in some patients as diet changes can reduce the frequency of seizures... more »

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3 votes
Ideate
(@jodyetheloner)

AoU Research Priorities Use Cases

Can you find a cure for tmau ( how to fix the FMO3 enzyme in our digestive system)

I have no clue how I would study it to be completely honest... But I have horrible body odor and terrible bad breath because of Trimethylaminuria (tmau). It is caused by a deficiency of flavin monooxygenase 3 (FMO3) secondary to mutations in the FMO3 gene. Please help me and others with this problem.

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10 votes
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(@drirene)

AoU Research Priorities Use Cases

Could the Precision Medicine Initiative Reduce Social Inequality?

The proposed study would identify microbial communities and metabolic profiles associated with stigmatized conditions such as idiopathic malodor or mental health. Working with systemic malodor/PATM community provides unprecedented opportunities to explore biomarkers of depression, social stress, diabetes, inflammatory diseases, dental, cardiovascular, and digestive health, exposure to antibiotics, lifestyle & dietary... more »

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219 votes
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(@jenna.norton)

AoU Research Priorities Use Cases

Does surgery to relieve obstruction from benign prostate enlargement (BPE) improve metabolic risk profile (MRP)?

Frequent and urgent urination secondary to obstruction from prostate enlargement may reduce physical activity and adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of men with incident surgery to relieve bladder outlet obstruction (BOO). We hypothesize relief of LUTS will decrease need to urinate, increase level of physical activity, and reduce MRP. Patient... more »

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17 votes
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(@jenna.norton)

AoU Research Priorities Use Cases

Does surgery to relieve obstruction from benign prostate enlargement (BPE) improve metabolic risk profile (MRP)?

Frequent and urgent urination secondary to obstruction from prostate enlargement may reduce physical activity and adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of men with incident surgery to relieve bladder outlet obstruction (BOO). We hypothesize relief of LUTS will decrease need to urinate, increase level of physical activity, and reduce MRP. Patient... more »

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17 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

Does midurethral sling surgery (MuSS) for stress urinary incontinence (SUI) improve metabolic risk profile?

SUI may contribute to reduced physical activity and poorer adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of women aged 18+ with incident MuSS to compare metabolic risk profile before and after successful surgery. We hypothesize successful MuSS will decrease need to urinate during day, increase level of physical activity, and reduce metabolic risk. Patient... more »

Voting

17 votes
Ideate
(@jenna.norton)

AoU Research Priorities Use Cases

Does midurethral sling surgery (MuSS) for stress urinary incontinence (SUI) improve metabolic risk profile?

SUI may contribute to reduced physical activity and poorer adherence to diuretics, thereby increasing metabolic risk profile. This study will identify a prospective subcohort of women aged 18+ with incident MuSS to compare metabolic risk profile before and after successful surgery. We hypothesize successful MuSS will decrease need to urinate during day, increase level of physical activity, and reduce metabolic risk. Patient... more »

Voting

17 votes
Ideate