(@atrenthamd)

AoU Research Priorities Use Cases

Exposures to environmental chemicals during pregnancy and effects on epigenetic biomarkers of metabolic syndrome and obesity

Obesity and breast cancer are leading cause of morbidity and mortality. Evidence strongly suggests that certain periods of life, including those during fetal development and pregnancy, influence risk of breast cancer later in life. Environmental chemicals may increase breast cancer risk-especially during pregnancy-by mimicking estrogen and other hormones. Epigenomic signatures present in the placenta uniquely capture... more »

Voting

9 votes
Ideate
(@evogtmann)

AoU Research Priorities Use Cases

Is the human oral and fecal microbiota associated with chronic disease risk factors, such as obesity and metabolic syndrome?

The human microbiota has been found to be associated with a number of health conditions, such as obesity. However, these studies have been relatively small and from convenience samples. It is important to understand how the human microbiota impacts these chronic disease risk factors in order to prevent future disease development. We propose collecting oral and fecal samples to determine associations with many chronic... more »

Voting

28 votes
Ideate
(@anon13)

AoU Research Priorities Use Cases

Does congenital sarcosinemia reduce the risk of depression?

Congenital sarcosinemia is a rare metabolic condition characterized by elevated levels of sarcosine in the blood and bodily fluids caused by an enzyme defect. It appears to be essentially harmless. Sarcosine has recently shown promise as an atypical antidepressant with no apparent side effects and a higher rate of efficacy than citalopram. A simple study would involve using a database of known sarcosinemia patients,... more »

Voting

4 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What genetic markers predict consequences of pregnancy associated hypertension & gestational diabetes for mothers & offspring?

This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.

Voting

26 votes
Ideate
(@nichd.allofus)

AoU Research Priorities Use Cases

What genetic markers predict consequences of pregnancy associated hypertension & gestational diabetes for mothers & offspring?

This study will focus on women who are pregnant at enrollment or become pregnant during the study and the offspring of observed pregnancies. The information will help to define genetic and epigenetic predictors of long-term effects of common pregnancy complications.

Voting

26 votes
Ideate