Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »
Defining heightened sensitivity as an increased hazard ratio for an association between air pollution and a health outcome, identify subsets of the population based on molecular factors, e.g. genetic variants, hypermethylated regions, which are at increases risk of adverse cardiovascular or pulmonary events during high air pollution days.
Congenital sarcosinemia is a rare metabolic condition characterized by elevated levels of sarcosine in the blood and bodily fluids caused by an enzyme defect. It appears to be essentially harmless. Sarcosine has recently shown promise as an atypical antidepressant with no apparent side effects and a higher rate of efficacy than citalopram. A simple study would involve using a database of known sarcosinemia patients,... more »