AoU Research Priorities Use Cases

AoU’s sample/measures uniquely allow for modeling high-burden disease pathways specified by the biopsychosocial ecological model

Biological, psychological & social domains interact at multiple levels (genes, human & environment microbiomes, stress, behavior, broad SES & environment) outlined by the biopsychosocial ecological model (BPSEM). The BPSEM specifies pathways aligned with the AoU pillars of biology, lifestyle, & environment. Simultaneous examination of the interacting domains and levels of the BPSEM is now computationally possible and... more »

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1 vote
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(@lisa.signorello)

AoU Research Priorities Use Cases

Is the seminal fluid microbiome associated with incident prostate cancer risk?

Prostate cancer has long been suspected to include an infectious etiology, although no agent has been identified. It is possible that one specific virus or bacterium is not significant, but rather the characteristics of the entire microbiota to which the prostate is exposed (e.g., the abundance and diversity of all microorganisms). This may be capturable by examining the seminal fluid microbiome.

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1 vote
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(@cdw0022)

AoU Research Priorities Use Cases

To what extent does gut permeability and dysbiosis affect systemic health?

There is a plethora of preliminary data connecting intestinal permeability to chronic inflammatory diseases. More work is needed in this area to determine causal mechanisms. Doing so could help in developing interventions and other targets in reducing chronic illnesses and improve quality of life.

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3 votes
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(@floresr2)

AoU Research Priorities Use Cases

Dietary and microbial-derived metabolites may modulate body weight and contribute to overweight and obesity.

Integrate multi-omic approaches (metabolomic, proteomic, inflammasome, microbiome analyses) with dietary assessment and clinical data in a nested cohort study. Dietary and/or microbial metabolites may modulate body weight and may influence other comorbidities. A comprehensive analysis of inflammatory and metabolic biomarkers of oxidative stress, nutritional assessment, short chain fatty acids and other microbial metabolites... more »

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14 votes
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(@floresr2)

AoU Research Priorities Use Cases

Dietary and microbial-derived metabolites may modulate body weight and contribute to overweight and obesity.

Integrate multi-omic approaches (metabolomic, proteomic, inflammasome, microbiome analyses) with dietary assessment and clinical data in a nested cohort study. Dietary and/or microbial metabolites may modulate body weight and may influence other comorbidities. A comprehensive analysis of inflammatory and metabolic biomarkers of oxidative stress, nutritional assessment, short chain fatty acids and other microbial metabolites... more »

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14 votes
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(@riscutag2)

AoU Research Priorities Use Cases

Evaluate Age-related Microbiota Changes and their impact in Health, and in Chronic Disease Prevention, Treatment and Progression

The microbiome variations have been associated with health and disease status in cross-sectional studies. There is a need to examine these associations in a longitudinal fashion and to establish baseline changes in health and disease over a lifespan. All of Us Together provides a game-changing amount of longitudinal data on enough individuals to begin to map the complex relationship between exposures (diet, antibiotics,... more »

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19 votes
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AoU Research Priorities Use Cases

Genetic, epigenetic, and microbiome contributions to hypertension

The goal would be to enhance our understanding of how social and environmental exposures, genomic factors, and gut microbiota interact to influence hypertension susceptibility and phenotype. This would require integrated analyses of genomic and other -omics data, exposures, and phenotype data, and could lead to insights that enable more targeted prevention and treatment. Inherent in this would be discovery of pathways... more »

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6 votes
Ideate

AoU Research Priorities Use Cases

Genetic, epigenetic, and microbiome contributions to hypertension

The goal would be to enhance our understanding of how social and environmental exposures, genomic factors, and gut microbiota interact to influence hypertension susceptibility and phenotype. This would require integrated analyses of genomic and other -omics data, exposures, and phenotype data, and could lead to insights that enable more targeted prevention and treatment. Inherent in this would be discovery of pathways... more »

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6 votes
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(@blp2125)

AoU Research Priorities Use Cases

Could adding fecal sampling to the "All of Us" campaign help resolve role of gut microbiome in complex disease risk?

The simple addition of fecal sample for the use of gut microbiome taxonomical assessment could prove a valuable resource for testing hypotheses about the gut flora as a target of, and contributor to myriad human health and disease states. Fecal sample collection is non-invasive and gut bacterial lab methods are becoming increasingly refined and high-throughput.

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15 votes
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(@blp2125)

AoU Research Priorities Use Cases

Could adding fecal sampling to the "All of Us" campaign help resolve role of gut microbiome in complex disease risk?

The simple addition of fecal sample for the use of gut microbiome taxonomical assessment could prove a valuable resource for testing hypotheses about the gut flora as a target of, and contributor to myriad human health and disease states. Fecal sample collection is non-invasive and gut bacterial lab methods are becoming increasingly refined and high-throughput.

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15 votes
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(@nsanchezpinto)

AoU Research Priorities Use Cases

Why do some previosuly healthy infants and toddlers develop severe lower respiratory tract infections with common viruses?

This would be designed as a prospective observational cohort study of children (infants to 2 year olds) with common seasonal respiratory viral illnesses (RSV, enterovirus/rhinovirus, human metapneumovirus, parainfluenza, influenza). Those with severe bronchiolitis/pneumonia requiring hospitalizations would then be compared to those who receive care as outpatients. The analysis would include clustering based on genetic... more »

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4 votes
Ideate
(@nsanchezpinto)

AoU Research Priorities Use Cases

Why do some previosuly healthy infants and toddlers develop severe lower respiratory tract infections with common viruses?

This would be designed as a prospective observational cohort study of children (infants to 2 year olds) with common seasonal respiratory viral illnesses (RSV, enterovirus/rhinovirus, human metapneumovirus, parainfluenza, influenza). Those with severe bronchiolitis/pneumonia requiring hospitalizations would then be compared to those who receive care as outpatients. The analysis would include clustering based on genetic... more »

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4 votes
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(@idsociety)

AoU Research Priorities Use Cases

Using human microbiome data to improve pathogenesis and treatment of infectious diseases

Precision microbiome engineering could be applied to vaccine delivery, immunology, drug-resistant infections, and post-surgical infections. Specific research questions re pathogenesis and treatment: - What aspects of the indigenous microbiota mediate colonization resistance against C. difficile, as well as other multi-drug resistant organisms such as carbapenamase-producing gram negative bacteria and vancomycin resistant... more »

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31 votes
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